Anaplerosis for Glutamate Synthesis in the Neonate and in Adulthood

Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiForskningfagfællebedømt

Standard

Anaplerosis for Glutamate Synthesis in the Neonate and in Adulthood. / Brekke, Eva; Morken, Tora Sund; Walls, Anne B; Waagepetersen, Helle; Schousboe, Arne; Sonnewald, Ursula.

The Glutamate/ GABA- Glutamine Cycle : Amino Acid Neurotransmitter Homeostasis. Bind 13 Springer, 2016. s. 43-58 (Advances in Neurobiology, Bind 13).

Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiForskningfagfællebedømt

Harvard

Brekke, E, Morken, TS, Walls, AB, Waagepetersen, H, Schousboe, A & Sonnewald, U 2016, Anaplerosis for Glutamate Synthesis in the Neonate and in Adulthood. i The Glutamate/ GABA- Glutamine Cycle : Amino Acid Neurotransmitter Homeostasis. bind 13, Springer, Advances in Neurobiology, bind 13, s. 43-58. https://doi.org/10.1007/978-3-319-45096-4_3

APA

Brekke, E., Morken, T. S., Walls, A. B., Waagepetersen, H., Schousboe, A., & Sonnewald, U. (2016). Anaplerosis for Glutamate Synthesis in the Neonate and in Adulthood. I The Glutamate/ GABA- Glutamine Cycle : Amino Acid Neurotransmitter Homeostasis (Bind 13, s. 43-58). Springer. Advances in Neurobiology, Bind. 13 https://doi.org/10.1007/978-3-319-45096-4_3

Vancouver

Brekke E, Morken TS, Walls AB, Waagepetersen H, Schousboe A, Sonnewald U. Anaplerosis for Glutamate Synthesis in the Neonate and in Adulthood. I The Glutamate/ GABA- Glutamine Cycle : Amino Acid Neurotransmitter Homeostasis. Bind 13. Springer. 2016. s. 43-58. (Advances in Neurobiology, Bind 13). https://doi.org/10.1007/978-3-319-45096-4_3

Author

Brekke, Eva ; Morken, Tora Sund ; Walls, Anne B ; Waagepetersen, Helle ; Schousboe, Arne ; Sonnewald, Ursula. / Anaplerosis for Glutamate Synthesis in the Neonate and in Adulthood. The Glutamate/ GABA- Glutamine Cycle : Amino Acid Neurotransmitter Homeostasis. Bind 13 Springer, 2016. s. 43-58 (Advances in Neurobiology, Bind 13).

Bibtex

@inbook{5a82ce80ec6a4dd0bccacaaced9de8a4,
title = "Anaplerosis for Glutamate Synthesis in the Neonate and in Adulthood",
abstract = "A central task of the tricarboxylic acid (TCA, Krebs, citric acid) cycle in brain is to provide precursors for biosynthesis of glutamate, GABA, aspartate and glutamine. Three of these amino acids are the partners in the intricate interaction between astrocytes and neurons and form the so-called glutamine-glutamate (GABA) cycle. The ketoacids α-ketoglutarate and oxaloacetate are removed from the cycle for this process. When something is removed from the TCA cycle it must be replaced to permit the continued function of this essential pathway, a process termed anaplerosis. This anaplerotic process in the brain is mainly carried out by pyruvate carboxylation performed by pyruvate carboxylase. The present book chapter gives an introduction and overview into this carboxylation and additionally anaplerosis mediated by propionyl-CoA carboxylase under physiological conditions in the adult and in the developing rodent brain. Furthermore, examples are given about pathological conditions in which anaplerosis is disturbed.",
author = "Eva Brekke and Morken, {Tora Sund} and Walls, {Anne B} and Helle Waagepetersen and Arne Schousboe and Ursula Sonnewald",
year = "2016",
doi = "10.1007/978-3-319-45096-4_3",
language = "English",
volume = "13",
series = "Advances in Neurobiology",
publisher = "Springer",
pages = "43--58",
booktitle = "The Glutamate/ GABA- Glutamine Cycle",

}

RIS

TY - CHAP

T1 - Anaplerosis for Glutamate Synthesis in the Neonate and in Adulthood

AU - Brekke, Eva

AU - Morken, Tora Sund

AU - Walls, Anne B

AU - Waagepetersen, Helle

AU - Schousboe, Arne

AU - Sonnewald, Ursula

PY - 2016

Y1 - 2016

N2 - A central task of the tricarboxylic acid (TCA, Krebs, citric acid) cycle in brain is to provide precursors for biosynthesis of glutamate, GABA, aspartate and glutamine. Three of these amino acids are the partners in the intricate interaction between astrocytes and neurons and form the so-called glutamine-glutamate (GABA) cycle. The ketoacids α-ketoglutarate and oxaloacetate are removed from the cycle for this process. When something is removed from the TCA cycle it must be replaced to permit the continued function of this essential pathway, a process termed anaplerosis. This anaplerotic process in the brain is mainly carried out by pyruvate carboxylation performed by pyruvate carboxylase. The present book chapter gives an introduction and overview into this carboxylation and additionally anaplerosis mediated by propionyl-CoA carboxylase under physiological conditions in the adult and in the developing rodent brain. Furthermore, examples are given about pathological conditions in which anaplerosis is disturbed.

AB - A central task of the tricarboxylic acid (TCA, Krebs, citric acid) cycle in brain is to provide precursors for biosynthesis of glutamate, GABA, aspartate and glutamine. Three of these amino acids are the partners in the intricate interaction between astrocytes and neurons and form the so-called glutamine-glutamate (GABA) cycle. The ketoacids α-ketoglutarate and oxaloacetate are removed from the cycle for this process. When something is removed from the TCA cycle it must be replaced to permit the continued function of this essential pathway, a process termed anaplerosis. This anaplerotic process in the brain is mainly carried out by pyruvate carboxylation performed by pyruvate carboxylase. The present book chapter gives an introduction and overview into this carboxylation and additionally anaplerosis mediated by propionyl-CoA carboxylase under physiological conditions in the adult and in the developing rodent brain. Furthermore, examples are given about pathological conditions in which anaplerosis is disturbed.

U2 - 10.1007/978-3-319-45096-4_3

DO - 10.1007/978-3-319-45096-4_3

M3 - Book chapter

VL - 13

T3 - Advances in Neurobiology

SP - 43

EP - 58

BT - The Glutamate/ GABA- Glutamine Cycle

PB - Springer

ER -

ID: 170012053