Allelic polymorphisms in the repeat and promoter regions of the interleukin-4 gene and malaria severity in Ghanaian children

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Standard

Allelic polymorphisms in the repeat and promoter regions of the interleukin-4 gene and malaria severity in Ghanaian children. / Gyan, B A; Goka, B; Cvetkovic, J T; Kurtzhals, J L; Adabayeri, V; Perlmann, H; Lefvert, A-K; Akanmori, B D; Troye-Blomberg, M.

I: Clinical and Experimental Immunology, Bind 138, Nr. 1, 2004, s. 145-50.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Gyan, BA, Goka, B, Cvetkovic, JT, Kurtzhals, JL, Adabayeri, V, Perlmann, H, Lefvert, A-K, Akanmori, BD & Troye-Blomberg, M 2004, 'Allelic polymorphisms in the repeat and promoter regions of the interleukin-4 gene and malaria severity in Ghanaian children' Clinical and Experimental Immunology, bind 138, nr. 1, s. 145-50. https://doi.org/10.1111/j.1365-2249.2004.02590.x

APA

Gyan, B. A., Goka, B., Cvetkovic, J. T., Kurtzhals, J. L., Adabayeri, V., Perlmann, H., ... Troye-Blomberg, M. (2004). Allelic polymorphisms in the repeat and promoter regions of the interleukin-4 gene and malaria severity in Ghanaian children. Clinical and Experimental Immunology, 138(1), 145-50. https://doi.org/10.1111/j.1365-2249.2004.02590.x

Vancouver

Gyan BA, Goka B, Cvetkovic JT, Kurtzhals JL, Adabayeri V, Perlmann H o.a. Allelic polymorphisms in the repeat and promoter regions of the interleukin-4 gene and malaria severity in Ghanaian children. Clinical and Experimental Immunology. 2004;138(1):145-50. https://doi.org/10.1111/j.1365-2249.2004.02590.x

Author

Gyan, B A ; Goka, B ; Cvetkovic, J T ; Kurtzhals, J L ; Adabayeri, V ; Perlmann, H ; Lefvert, A-K ; Akanmori, B D ; Troye-Blomberg, M. / Allelic polymorphisms in the repeat and promoter regions of the interleukin-4 gene and malaria severity in Ghanaian children. I: Clinical and Experimental Immunology. 2004 ; Bind 138, Nr. 1. s. 145-50.

Bibtex

@article{bceae1a00ce811df825d000ea68e967b,
title = "Allelic polymorphisms in the repeat and promoter regions of the interleukin-4 gene and malaria severity in Ghanaian children",
abstract = "Immunoglobulin E has been associated with severe malaria suggesting a regulatory role for interleukin (IL)-4 and/or IgE in the pathogenesis of severe malaria. We have investigated possible associations between polymorphisms in the IL-4 repeat region (intron 3) and promoter regions (IL-4 +33CT and - 590CT) in Ghanaian children with severe malaria. There was a significantly higher frequency of IL-4 intron-3 B1B1 genotype in the cerebral malaria group [P < 0.0001, odds ratio (OR) = 8.7]. The genotype and allele frequencies of the IL-4 -590 and +33 polymorphisms did not differ between the four study groups. Carriers of IL-4 +33T/-590T with cerebral malaria had elevated total IgE compared to non-carriers (P = 0.03). Our data suggest that IL-4 and/or IgE play a regulatory role in the pathogenesis of severe or complicated malaria.",
author = "Gyan, {B A} and B Goka and Cvetkovic, {J T} and Kurtzhals, {J L} and V Adabayeri and H Perlmann and A-K Lefvert and Akanmori, {B D} and M Troye-Blomberg",
note = "Keywords: Alleles; Antibodies, Protozoan; Child; Child, Preschool; Gene Frequency; Genotype; Ghana; Humans; Immunoglobulin E; Infant; Interleukin-4; Linkage Disequilibrium; Malaria, Cerebral; Malaria, Falciparum; Parasitemia; Polymorphism, Genetic; Promoter Regions, Genetic; Repetitive Sequences, Nucleic Acid; Severity of Illness Index",
year = "2004",
doi = "10.1111/j.1365-2249.2004.02590.x",
language = "English",
volume = "138",
pages = "145--50",
journal = "Clinical and Experimental Immunology",
issn = "0009-9104",
publisher = "Wiley-Blackwell",
number = "1",

}

RIS

TY - JOUR

T1 - Allelic polymorphisms in the repeat and promoter regions of the interleukin-4 gene and malaria severity in Ghanaian children

AU - Gyan, B A

AU - Goka, B

AU - Cvetkovic, J T

AU - Kurtzhals, J L

AU - Adabayeri, V

AU - Perlmann, H

AU - Lefvert, A-K

AU - Akanmori, B D

AU - Troye-Blomberg, M

N1 - Keywords: Alleles; Antibodies, Protozoan; Child; Child, Preschool; Gene Frequency; Genotype; Ghana; Humans; Immunoglobulin E; Infant; Interleukin-4; Linkage Disequilibrium; Malaria, Cerebral; Malaria, Falciparum; Parasitemia; Polymorphism, Genetic; Promoter Regions, Genetic; Repetitive Sequences, Nucleic Acid; Severity of Illness Index

PY - 2004

Y1 - 2004

N2 - Immunoglobulin E has been associated with severe malaria suggesting a regulatory role for interleukin (IL)-4 and/or IgE in the pathogenesis of severe malaria. We have investigated possible associations between polymorphisms in the IL-4 repeat region (intron 3) and promoter regions (IL-4 +33CT and - 590CT) in Ghanaian children with severe malaria. There was a significantly higher frequency of IL-4 intron-3 B1B1 genotype in the cerebral malaria group [P < 0.0001, odds ratio (OR) = 8.7]. The genotype and allele frequencies of the IL-4 -590 and +33 polymorphisms did not differ between the four study groups. Carriers of IL-4 +33T/-590T with cerebral malaria had elevated total IgE compared to non-carriers (P = 0.03). Our data suggest that IL-4 and/or IgE play a regulatory role in the pathogenesis of severe or complicated malaria.

AB - Immunoglobulin E has been associated with severe malaria suggesting a regulatory role for interleukin (IL)-4 and/or IgE in the pathogenesis of severe malaria. We have investigated possible associations between polymorphisms in the IL-4 repeat region (intron 3) and promoter regions (IL-4 +33CT and - 590CT) in Ghanaian children with severe malaria. There was a significantly higher frequency of IL-4 intron-3 B1B1 genotype in the cerebral malaria group [P < 0.0001, odds ratio (OR) = 8.7]. The genotype and allele frequencies of the IL-4 -590 and +33 polymorphisms did not differ between the four study groups. Carriers of IL-4 +33T/-590T with cerebral malaria had elevated total IgE compared to non-carriers (P = 0.03). Our data suggest that IL-4 and/or IgE play a regulatory role in the pathogenesis of severe or complicated malaria.

U2 - 10.1111/j.1365-2249.2004.02590.x

DO - 10.1111/j.1365-2249.2004.02590.x

M3 - Journal article

VL - 138

SP - 145

EP - 150

JO - Clinical and Experimental Immunology

JF - Clinical and Experimental Immunology

SN - 0009-9104

IS - 1

ER -

ID: 17274412