Acute effects of N-terminal progastrin fragments on gastric acid secretion in man

Publikation: Bidrag til tidsskriftTidsskriftartikel

Standard

Acute effects of N-terminal progastrin fragments on gastric acid secretion in man. / Goetze, Jens P; Hansen, Carsten P; Rehfeld, Jens F.

I: Physiological Reports, Bind 5, Nr. 5, e13164, 2017.

Publikation: Bidrag til tidsskriftTidsskriftartikel

Harvard

Goetze, JP, Hansen, CP & Rehfeld, JF 2017, 'Acute effects of N-terminal progastrin fragments on gastric acid secretion in man', Physiological Reports, bind 5, nr. 5, e13164. https://doi.org/10.14814/phy2.13164

APA

Goetze, J. P., Hansen, C. P., & Rehfeld, J. F. (2017). Acute effects of N-terminal progastrin fragments on gastric acid secretion in man. Physiological Reports, 5(5), [e13164]. https://doi.org/10.14814/phy2.13164

Vancouver

Goetze JP, Hansen CP, Rehfeld JF. Acute effects of N-terminal progastrin fragments on gastric acid secretion in man. Physiological Reports. 2017;5(5). e13164. https://doi.org/10.14814/phy2.13164

Author

Goetze, Jens P ; Hansen, Carsten P ; Rehfeld, Jens F. / Acute effects of N-terminal progastrin fragments on gastric acid secretion in man. I: Physiological Reports. 2017 ; Bind 5, Nr. 5.

Bibtex

@article{16ef901375cf4d1282d6e91040a9d2a2,
title = "Acute effects of N-terminal progastrin fragments on gastric acid secretion in man",
abstract = "We previously identified an N-terminal fragment of progastrin in human antrum and plasma, where it circulates in high concentrations. In this study, we examined the effects of N-terminal progastrin fragments on gastric acid secretion by infusion in healthy individuals. Increasing doses of progastrin fragment 1-35 were infused intravenously during constant gastric acid stimulation by gastrin-17. In addition, the effects of progastrin fragment 1-35, fragment 6-35, and fragment 1-19 on gastrin-17 stimulated acid secretion were tested. The gastrin-17 stimulated acid secretion decreased 30{\%} after administration of a high dose of progastrin fragment 1-35 (P < 0.05). In extension, a 1-h infusion of fragment 1-35 also decreased gastric acid output. In contrast, fragment 6-35 did not affect acid secretion, and a single infusion of gastrin-17 alone did not reveal fading of gastric acid output during the time course of the experiments. The results show that N-terminal fragments of progastrin may acutely affect gastrin-stimulated gastric acid secretion in vivo. Structure-function analysis suggests that the N-terminal pentapeptide of progastrin is required for the effect.",
keywords = "Adult, Female, Gastric Acid/secretion, Gastric Mucosa/drug effects, Gastrins/pharmacology, Humans, Male, Peptide Fragments/pharmacology, Protein Precursors/pharmacology, Young Adult",
author = "Goetze, {Jens P} and Hansen, {Carsten P} and Rehfeld, {Jens F}",
note = "{\circledC} 2017 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.",
year = "2017",
doi = "10.14814/phy2.13164",
language = "English",
volume = "5",
journal = "Physiological Reports",
issn = "2051-817X",
publisher = "Wiley Periodicals, Inc.",
number = "5",

}

RIS

TY - JOUR

T1 - Acute effects of N-terminal progastrin fragments on gastric acid secretion in man

AU - Goetze, Jens P

AU - Hansen, Carsten P

AU - Rehfeld, Jens F

N1 - © 2017 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

PY - 2017

Y1 - 2017

N2 - We previously identified an N-terminal fragment of progastrin in human antrum and plasma, where it circulates in high concentrations. In this study, we examined the effects of N-terminal progastrin fragments on gastric acid secretion by infusion in healthy individuals. Increasing doses of progastrin fragment 1-35 were infused intravenously during constant gastric acid stimulation by gastrin-17. In addition, the effects of progastrin fragment 1-35, fragment 6-35, and fragment 1-19 on gastrin-17 stimulated acid secretion were tested. The gastrin-17 stimulated acid secretion decreased 30% after administration of a high dose of progastrin fragment 1-35 (P < 0.05). In extension, a 1-h infusion of fragment 1-35 also decreased gastric acid output. In contrast, fragment 6-35 did not affect acid secretion, and a single infusion of gastrin-17 alone did not reveal fading of gastric acid output during the time course of the experiments. The results show that N-terminal fragments of progastrin may acutely affect gastrin-stimulated gastric acid secretion in vivo. Structure-function analysis suggests that the N-terminal pentapeptide of progastrin is required for the effect.

AB - We previously identified an N-terminal fragment of progastrin in human antrum and plasma, where it circulates in high concentrations. In this study, we examined the effects of N-terminal progastrin fragments on gastric acid secretion by infusion in healthy individuals. Increasing doses of progastrin fragment 1-35 were infused intravenously during constant gastric acid stimulation by gastrin-17. In addition, the effects of progastrin fragment 1-35, fragment 6-35, and fragment 1-19 on gastrin-17 stimulated acid secretion were tested. The gastrin-17 stimulated acid secretion decreased 30% after administration of a high dose of progastrin fragment 1-35 (P < 0.05). In extension, a 1-h infusion of fragment 1-35 also decreased gastric acid output. In contrast, fragment 6-35 did not affect acid secretion, and a single infusion of gastrin-17 alone did not reveal fading of gastric acid output during the time course of the experiments. The results show that N-terminal fragments of progastrin may acutely affect gastrin-stimulated gastric acid secretion in vivo. Structure-function analysis suggests that the N-terminal pentapeptide of progastrin is required for the effect.

KW - Adult

KW - Female

KW - Gastric Acid/secretion

KW - Gastric Mucosa/drug effects

KW - Gastrins/pharmacology

KW - Humans

KW - Male

KW - Peptide Fragments/pharmacology

KW - Protein Precursors/pharmacology

KW - Young Adult

U2 - 10.14814/phy2.13164

DO - 10.14814/phy2.13164

M3 - Journal article

VL - 5

JO - Physiological Reports

JF - Physiological Reports

SN - 2051-817X

IS - 5

M1 - e13164

ER -

ID: 196133419