A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults. / Hansen, Lea Benedicte Skov; Roager, Henrik Munch; Søndertoft, Nadja Buus; Gøbel, Rikke Juul; Kristensen, Mette Bredal; Vallès-Colomer, Mireia; Vieira-Silva, Sara; Ibrügger, Sabine; Lind, Mads Vendelbo; Mærkedahl, Rasmus Baadsgaard; Bahl, Martin Iain; Madsen, Mia Linda; Havelund, Jesper; Falony, Gwen; Tetens, Inge ; Nielsen, Trine; Allin, Kristine Højgaard; Frandsen, Henrik Lund; Hartmann, Bolette; Holst, Jens Juul; Sparholt, Morten H; Holck, Jesper; Blennow, Andreas; Moll, Janne Marie; Meyer, Anne S; Hoppe, Camilla; Poulsen, Jørgen H; Carvalho, Vera; Sagnelli, Domenico; Dalgaard, Marlene Danner; Christensen, Anders Fogh; Lydolph, Magnus; Ross, Alistair B; Villas-Bôas, Silas G; Brix, Susanne; Sicheritz-Pontén, Thomas; Buschard, Karsten; Linneberg, Allan René; Rumessen, Jüri Johannes; Ekstrøm, Claus Thorn; Ritz, Christian; Kristiansen, Karsten; Nielsen, H Bjørn; Vestergaard, Henrik; Færgeman, Nils J; Raes, Jeroen; Frøkiær, Hanne; Hansen, Torben; Lauritzen, Lotte; Gupta, Ramneek; Licht, Tine Rask; Pedersen, Oluf Borbye.

I: Nature Communications, Bind 9, 4630, 2018.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Hansen, LBS, Roager, HM, Søndertoft, NB, Gøbel, RJ, Kristensen, MB, Vallès-Colomer, M, Vieira-Silva, S, Ibrügger, S, Lind, MV, Mærkedahl, RB, Bahl, MI, Madsen, ML, Havelund, J, Falony, G, Tetens, I, Nielsen, T, Allin, KH, Frandsen, HL, Hartmann, B, Holst, JJ, Sparholt, MH, Holck, J, Blennow, A, Moll, JM, Meyer, AS, Hoppe, C, Poulsen, JH, Carvalho, V, Sagnelli, D, Dalgaard, MD, Christensen, AF, Lydolph, M, Ross, AB, Villas-Bôas, SG, Brix, S, Sicheritz-Pontén, T, Buschard, K, Linneberg, AR, Rumessen, JJ, Ekstrøm, CT, Ritz, C, Kristiansen, K, Nielsen, HB, Vestergaard, H, Færgeman, NJ, Raes, J, Frøkiær, H, Hansen, T, Lauritzen, L, Gupta, R, Licht, TR & Pedersen, OB 2018, 'A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults', Nature Communications, bind 9, 4630. https://doi.org/10.1038/s41467-018-07019-x

APA

Hansen, L. B. S., Roager, H. M., Søndertoft, N. B., Gøbel, R. J., Kristensen, M. B., Vallès-Colomer, M., ... Pedersen, O. B. (2018). A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults. Nature Communications, 9, [4630]. https://doi.org/10.1038/s41467-018-07019-x

Vancouver

Hansen LBS, Roager HM, Søndertoft NB, Gøbel RJ, Kristensen MB, Vallès-Colomer M o.a. A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults. Nature Communications. 2018;9. 4630. https://doi.org/10.1038/s41467-018-07019-x

Author

Hansen, Lea Benedicte Skov ; Roager, Henrik Munch ; Søndertoft, Nadja Buus ; Gøbel, Rikke Juul ; Kristensen, Mette Bredal ; Vallès-Colomer, Mireia ; Vieira-Silva, Sara ; Ibrügger, Sabine ; Lind, Mads Vendelbo ; Mærkedahl, Rasmus Baadsgaard ; Bahl, Martin Iain ; Madsen, Mia Linda ; Havelund, Jesper ; Falony, Gwen ; Tetens, Inge ; Nielsen, Trine ; Allin, Kristine Højgaard ; Frandsen, Henrik Lund ; Hartmann, Bolette ; Holst, Jens Juul ; Sparholt, Morten H ; Holck, Jesper ; Blennow, Andreas ; Moll, Janne Marie ; Meyer, Anne S ; Hoppe, Camilla ; Poulsen, Jørgen H ; Carvalho, Vera ; Sagnelli, Domenico ; Dalgaard, Marlene Danner ; Christensen, Anders Fogh ; Lydolph, Magnus ; Ross, Alistair B ; Villas-Bôas, Silas G ; Brix, Susanne ; Sicheritz-Pontén, Thomas ; Buschard, Karsten ; Linneberg, Allan René ; Rumessen, Jüri Johannes ; Ekstrøm, Claus Thorn ; Ritz, Christian ; Kristiansen, Karsten ; Nielsen, H Bjørn ; Vestergaard, Henrik ; Færgeman, Nils J ; Raes, Jeroen ; Frøkiær, Hanne ; Hansen, Torben ; Lauritzen, Lotte ; Gupta, Ramneek ; Licht, Tine Rask ; Pedersen, Oluf Borbye. / A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults. I: Nature Communications. 2018 ; Bind 9.

Bibtex

@article{32f6a2876b334713905805a50fee0140,
title = "A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults",
abstract = "Adherence to a low-gluten diet has become increasingly common in parts of the general population. However, the effects of reducing gluten-rich food items including wheat, barley and rye cereals in healthy adults are unclear. Here, we undertook a randomised, controlled, cross-over trial involving 60 middle-aged Danish adults without known disorders with two 8-week interventions comparing a low-gluten diet (2 g gluten per day) and a high-gluten diet (18 g gluten per day), separated by a washout period of at least six weeks with habitual diet (12 g gluten per day). We find that, in comparison with a high-gluten diet, a low-gluten diet induces moderate changes in the intestinal microbiome, reduces fasting and postprandial hydrogen exhalation, and leads to improvements in self-reported bloating. These observations suggest that most of the effects of a low-gluten diet in non-coeliac adults may be driven by qualitative changes in dietary fibres.",
keywords = "The Faculty of Science, Low-gluten diet, Intestinal microbiome, Dietary fibres",
author = "Hansen, {Lea Benedicte Skov} and Roager, {Henrik Munch} and S{\o}ndertoft, {Nadja Buus} and G{\o}bel, {Rikke Juul} and Kristensen, {Mette Bredal} and Mireia Vall{\`e}s-Colomer and Sara Vieira-Silva and Sabine Ibr{\"u}gger and Lind, {Mads Vendelbo} and M{\ae}rkedahl, {Rasmus Baadsgaard} and Bahl, {Martin Iain} and Madsen, {Mia Linda} and Jesper Havelund and Gwen Falony and Inge Tetens and Trine Nielsen and Allin, {Kristine H{\o}jgaard} and Frandsen, {Henrik Lund} and Bolette Hartmann and Holst, {Jens Juul} and Sparholt, {Morten H} and Jesper Holck and Andreas Blennow and Moll, {Janne Marie} and Meyer, {Anne S} and Camilla Hoppe and Poulsen, {J{\o}rgen H} and Vera Carvalho and Domenico Sagnelli and Dalgaard, {Marlene Danner} and Christensen, {Anders Fogh} and Magnus Lydolph and Ross, {Alistair B} and Villas-B{\^o}as, {Silas G} and Susanne Brix and Thomas Sicheritz-Pont{\'e}n and Karsten Buschard and Linneberg, {Allan Ren{\'e}} and Rumessen, {J{\"u}ri Johannes} and Ekstr{\o}m, {Claus Thorn} and Christian Ritz and Karsten Kristiansen and Nielsen, {H Bj{\o}rn} and Henrik Vestergaard and F{\ae}rgeman, {Nils J} and Jeroen Raes and Hanne Fr{\o}ki{\ae}r and Torben Hansen and Lotte Lauritzen and Ramneek Gupta and Licht, {Tine Rask} and Pedersen, {Oluf Borbye}",
note = "CURIS 2018 NEXS 380",
year = "2018",
doi = "10.1038/s41467-018-07019-x",
language = "English",
volume = "9",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults

AU - Hansen, Lea Benedicte Skov

AU - Roager, Henrik Munch

AU - Søndertoft, Nadja Buus

AU - Gøbel, Rikke Juul

AU - Kristensen, Mette Bredal

AU - Vallès-Colomer, Mireia

AU - Vieira-Silva, Sara

AU - Ibrügger, Sabine

AU - Lind, Mads Vendelbo

AU - Mærkedahl, Rasmus Baadsgaard

AU - Bahl, Martin Iain

AU - Madsen, Mia Linda

AU - Havelund, Jesper

AU - Falony, Gwen

AU - Tetens, Inge

AU - Nielsen, Trine

AU - Allin, Kristine Højgaard

AU - Frandsen, Henrik Lund

AU - Hartmann, Bolette

AU - Holst, Jens Juul

AU - Sparholt, Morten H

AU - Holck, Jesper

AU - Blennow, Andreas

AU - Moll, Janne Marie

AU - Meyer, Anne S

AU - Hoppe, Camilla

AU - Poulsen, Jørgen H

AU - Carvalho, Vera

AU - Sagnelli, Domenico

AU - Dalgaard, Marlene Danner

AU - Christensen, Anders Fogh

AU - Lydolph, Magnus

AU - Ross, Alistair B

AU - Villas-Bôas, Silas G

AU - Brix, Susanne

AU - Sicheritz-Pontén, Thomas

AU - Buschard, Karsten

AU - Linneberg, Allan René

AU - Rumessen, Jüri Johannes

AU - Ekstrøm, Claus Thorn

AU - Ritz, Christian

AU - Kristiansen, Karsten

AU - Nielsen, H Bjørn

AU - Vestergaard, Henrik

AU - Færgeman, Nils J

AU - Raes, Jeroen

AU - Frøkiær, Hanne

AU - Hansen, Torben

AU - Lauritzen, Lotte

AU - Gupta, Ramneek

AU - Licht, Tine Rask

AU - Pedersen, Oluf Borbye

N1 - CURIS 2018 NEXS 380

PY - 2018

Y1 - 2018

N2 - Adherence to a low-gluten diet has become increasingly common in parts of the general population. However, the effects of reducing gluten-rich food items including wheat, barley and rye cereals in healthy adults are unclear. Here, we undertook a randomised, controlled, cross-over trial involving 60 middle-aged Danish adults without known disorders with two 8-week interventions comparing a low-gluten diet (2 g gluten per day) and a high-gluten diet (18 g gluten per day), separated by a washout period of at least six weeks with habitual diet (12 g gluten per day). We find that, in comparison with a high-gluten diet, a low-gluten diet induces moderate changes in the intestinal microbiome, reduces fasting and postprandial hydrogen exhalation, and leads to improvements in self-reported bloating. These observations suggest that most of the effects of a low-gluten diet in non-coeliac adults may be driven by qualitative changes in dietary fibres.

AB - Adherence to a low-gluten diet has become increasingly common in parts of the general population. However, the effects of reducing gluten-rich food items including wheat, barley and rye cereals in healthy adults are unclear. Here, we undertook a randomised, controlled, cross-over trial involving 60 middle-aged Danish adults without known disorders with two 8-week interventions comparing a low-gluten diet (2 g gluten per day) and a high-gluten diet (18 g gluten per day), separated by a washout period of at least six weeks with habitual diet (12 g gluten per day). We find that, in comparison with a high-gluten diet, a low-gluten diet induces moderate changes in the intestinal microbiome, reduces fasting and postprandial hydrogen exhalation, and leads to improvements in self-reported bloating. These observations suggest that most of the effects of a low-gluten diet in non-coeliac adults may be driven by qualitative changes in dietary fibres.

KW - The Faculty of Science

KW - Low-gluten diet

KW - Intestinal microbiome

KW - Dietary fibres

U2 - 10.1038/s41467-018-07019-x

DO - 10.1038/s41467-018-07019-x

M3 - Journal article

VL - 9

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 4630

ER -

ID: 208869531