A Distinct Population of Microglia Supports Adult Neurogenesis in the Subventricular Zone

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A Distinct Population of Microglia Supports Adult Neurogenesis in the Subventricular Zone. / Ribeiro Xavier, Anna L.; Kress, Benjamin T.; Goldman, Steven A.; Lacerda de Menezes, João R.; Nedergaard, Maiken.

I: The Journal of neuroscience : the official journal of the Society for Neuroscience, Bind 35, Nr. 34, 26.08.2015, s. 11848-11861.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Ribeiro Xavier, AL, Kress, BT, Goldman, SA, Lacerda de Menezes, JR & Nedergaard, M 2015, 'A Distinct Population of Microglia Supports Adult Neurogenesis in the Subventricular Zone', The Journal of neuroscience : the official journal of the Society for Neuroscience, bind 35, nr. 34, s. 11848-11861. https://doi.org/10.1523/JNEUROSCI.1217-15.2015

APA

Ribeiro Xavier, A. L., Kress, B. T., Goldman, S. A., Lacerda de Menezes, J. R., & Nedergaard, M. (2015). A Distinct Population of Microglia Supports Adult Neurogenesis in the Subventricular Zone. The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(34), 11848-11861. https://doi.org/10.1523/JNEUROSCI.1217-15.2015

Vancouver

Ribeiro Xavier AL, Kress BT, Goldman SA, Lacerda de Menezes JR, Nedergaard M. A Distinct Population of Microglia Supports Adult Neurogenesis in the Subventricular Zone. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2015 aug 26;35(34):11848-11861. https://doi.org/10.1523/JNEUROSCI.1217-15.2015

Author

Ribeiro Xavier, Anna L. ; Kress, Benjamin T. ; Goldman, Steven A. ; Lacerda de Menezes, João R. ; Nedergaard, Maiken. / A Distinct Population of Microglia Supports Adult Neurogenesis in the Subventricular Zone. I: The Journal of neuroscience : the official journal of the Society for Neuroscience. 2015 ; Bind 35, Nr. 34. s. 11848-11861.

Bibtex

@article{160948cc98e34fd686a79d12c9306b34,
title = "A Distinct Population of Microglia Supports Adult Neurogenesis in the Subventricular Zone",
abstract = "Microglia are involved in synaptic pruning both in development and in the mature CNS. In this study, we investigated whether microglia might further contribute to circuit plasticity by modulating neuronal recruitment from the neurogenic subventricular zone (SVZ) of the adult mouse striatum. We found that microglia residing in the SVZ and adjacent rostral migratory stream (RMS) comprise a morphologically and antigenically distinct phenotype of immune effectors. Whereas exhibiting characteristics of alternatively activated microglia, the SVZ/RMS microglia were clearly distinguished by their low expression of purinoceptors and lack of ATP-elicitable chemotaxis. Furthermore, the in vivo depletion of these microglia hampered the survival and migration of newly generated neuroblasts through the RMS to the olfactory bulb. SVZ and RMS microglia thus appear to comprise a functionally distinct class that is selectively adapted to the support and direction of neuronal integration into the olfactory circuitry. Therefore, this unique microglial subpopulation may serve as a novel target with which to modulate cellular addition from endogenous neural stem and progenitor cells of the adult brain.SIGNIFICANCE STATEMENT: Microglial cells are a specialized population of macrophages in the CNS, playing key roles as immune mediators. As integral components in the CNS, the microglia stand out for using the same mechanisms, phagocytosis and cytochemokine release, to promote homeostasis, synaptic pruning, and neural circuitry sculpture. Here, we addressed microglial functions in the subventricular zone (SVZ), the major postnatal neurogenic niche. Our results depict microglia as a conspicuous component of SVZ and its anterior extension, the rostral migratory stream, a pathway used by neuroblasts during their transit toward olfactory bulb layers. In addition to other unique populations residing in the SVZ niche, microglia display distinct morphofunctional properties that boost neuronal progenitor survival and migration in the mammalian brain.",
keywords = "Animals, Animals, Newborn, Female, Lateral Ventricles, Male, Mice, Mice, 129 Strain, Mice, Inbred C57BL, Mice, Transgenic, Microglia, Neural Stem Cells, Neurogenesis",
author = "{Ribeiro Xavier}, {Anna L.} and Kress, {Benjamin T.} and Goldman, {Steven A.} and {Lacerda de Menezes}, {Jo{\~a}o R.} and Maiken Nedergaard",
note = "Copyright {\circledC} 2015 the authors 0270-6474/15/3511848-14$15.00/0.",
year = "2015",
month = "8",
day = "26",
doi = "10.1523/JNEUROSCI.1217-15.2015",
language = "English",
volume = "35",
pages = "11848--11861",
journal = "The Journal of neuroscience : the official journal of the Society for Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "34",

}

RIS

TY - JOUR

T1 - A Distinct Population of Microglia Supports Adult Neurogenesis in the Subventricular Zone

AU - Ribeiro Xavier, Anna L.

AU - Kress, Benjamin T.

AU - Goldman, Steven A.

AU - Lacerda de Menezes, João R.

AU - Nedergaard, Maiken

N1 - Copyright © 2015 the authors 0270-6474/15/3511848-14$15.00/0.

PY - 2015/8/26

Y1 - 2015/8/26

N2 - Microglia are involved in synaptic pruning both in development and in the mature CNS. In this study, we investigated whether microglia might further contribute to circuit plasticity by modulating neuronal recruitment from the neurogenic subventricular zone (SVZ) of the adult mouse striatum. We found that microglia residing in the SVZ and adjacent rostral migratory stream (RMS) comprise a morphologically and antigenically distinct phenotype of immune effectors. Whereas exhibiting characteristics of alternatively activated microglia, the SVZ/RMS microglia were clearly distinguished by their low expression of purinoceptors and lack of ATP-elicitable chemotaxis. Furthermore, the in vivo depletion of these microglia hampered the survival and migration of newly generated neuroblasts through the RMS to the olfactory bulb. SVZ and RMS microglia thus appear to comprise a functionally distinct class that is selectively adapted to the support and direction of neuronal integration into the olfactory circuitry. Therefore, this unique microglial subpopulation may serve as a novel target with which to modulate cellular addition from endogenous neural stem and progenitor cells of the adult brain.SIGNIFICANCE STATEMENT: Microglial cells are a specialized population of macrophages in the CNS, playing key roles as immune mediators. As integral components in the CNS, the microglia stand out for using the same mechanisms, phagocytosis and cytochemokine release, to promote homeostasis, synaptic pruning, and neural circuitry sculpture. Here, we addressed microglial functions in the subventricular zone (SVZ), the major postnatal neurogenic niche. Our results depict microglia as a conspicuous component of SVZ and its anterior extension, the rostral migratory stream, a pathway used by neuroblasts during their transit toward olfactory bulb layers. In addition to other unique populations residing in the SVZ niche, microglia display distinct morphofunctional properties that boost neuronal progenitor survival and migration in the mammalian brain.

AB - Microglia are involved in synaptic pruning both in development and in the mature CNS. In this study, we investigated whether microglia might further contribute to circuit plasticity by modulating neuronal recruitment from the neurogenic subventricular zone (SVZ) of the adult mouse striatum. We found that microglia residing in the SVZ and adjacent rostral migratory stream (RMS) comprise a morphologically and antigenically distinct phenotype of immune effectors. Whereas exhibiting characteristics of alternatively activated microglia, the SVZ/RMS microglia were clearly distinguished by their low expression of purinoceptors and lack of ATP-elicitable chemotaxis. Furthermore, the in vivo depletion of these microglia hampered the survival and migration of newly generated neuroblasts through the RMS to the olfactory bulb. SVZ and RMS microglia thus appear to comprise a functionally distinct class that is selectively adapted to the support and direction of neuronal integration into the olfactory circuitry. Therefore, this unique microglial subpopulation may serve as a novel target with which to modulate cellular addition from endogenous neural stem and progenitor cells of the adult brain.SIGNIFICANCE STATEMENT: Microglial cells are a specialized population of macrophages in the CNS, playing key roles as immune mediators. As integral components in the CNS, the microglia stand out for using the same mechanisms, phagocytosis and cytochemokine release, to promote homeostasis, synaptic pruning, and neural circuitry sculpture. Here, we addressed microglial functions in the subventricular zone (SVZ), the major postnatal neurogenic niche. Our results depict microglia as a conspicuous component of SVZ and its anterior extension, the rostral migratory stream, a pathway used by neuroblasts during their transit toward olfactory bulb layers. In addition to other unique populations residing in the SVZ niche, microglia display distinct morphofunctional properties that boost neuronal progenitor survival and migration in the mammalian brain.

KW - Animals

KW - Animals, Newborn

KW - Female

KW - Lateral Ventricles

KW - Male

KW - Mice

KW - Mice, 129 Strain

KW - Mice, Inbred C57BL

KW - Mice, Transgenic

KW - Microglia

KW - Neural Stem Cells

KW - Neurogenesis

U2 - 10.1523/JNEUROSCI.1217-15.2015

DO - 10.1523/JNEUROSCI.1217-15.2015

M3 - Journal article

VL - 35

SP - 11848

EP - 11861

JO - The Journal of neuroscience : the official journal of the Society for Neuroscience

JF - The Journal of neuroscience : the official journal of the Society for Neuroscience

SN - 0270-6474

IS - 34

ER -

ID: 152955832