A Comparison of Endoscopic Ultrasound Guided Biopsy and Positron Emission Tomography with Integrated Computed Tomography in Lung Cancer Staging

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A Comparison of Endoscopic Ultrasound Guided Biopsy and Positron Emission Tomography with Integrated Computed Tomography in Lung Cancer Staging. / Larsen, Stine Schmidt; Vilmann, P; Krasnik, K; Dirksen, Asger; Clementsen, P; Skov, Birgit G; Jacobsen, Grete Krag; Lassen, U; Eigtved, Annika; Berthelsen, Anne Kiil; Mortensen, Jann; Hoejgaard, Liselotte.

I: Current Health Sciences Journal, Bind 35, Nr. 1, 01.2009, s. 5-12.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Larsen, SS, Vilmann, P, Krasnik, K, Dirksen, A, Clementsen, P, Skov, BG, Jacobsen, GK, Lassen, U, Eigtved, A, Berthelsen, AK, Mortensen, J & Hoejgaard, L 2009, 'A Comparison of Endoscopic Ultrasound Guided Biopsy and Positron Emission Tomography with Integrated Computed Tomography in Lung Cancer Staging', Current Health Sciences Journal, bind 35, nr. 1, s. 5-12.

APA

Larsen, S. S., Vilmann, P., Krasnik, K., Dirksen, A., Clementsen, P., Skov, B. G., ... Hoejgaard, L. (2009). A Comparison of Endoscopic Ultrasound Guided Biopsy and Positron Emission Tomography with Integrated Computed Tomography in Lung Cancer Staging. Current Health Sciences Journal, 35(1), 5-12.

Vancouver

Larsen SS, Vilmann P, Krasnik K, Dirksen A, Clementsen P, Skov BG o.a. A Comparison of Endoscopic Ultrasound Guided Biopsy and Positron Emission Tomography with Integrated Computed Tomography in Lung Cancer Staging. Current Health Sciences Journal. 2009 jan;35(1):5-12.

Author

Larsen, Stine Schmidt ; Vilmann, P ; Krasnik, K ; Dirksen, Asger ; Clementsen, P ; Skov, Birgit G ; Jacobsen, Grete Krag ; Lassen, U ; Eigtved, Annika ; Berthelsen, Anne Kiil ; Mortensen, Jann ; Hoejgaard, Liselotte. / A Comparison of Endoscopic Ultrasound Guided Biopsy and Positron Emission Tomography with Integrated Computed Tomography in Lung Cancer Staging. I: Current Health Sciences Journal. 2009 ; Bind 35, Nr. 1. s. 5-12.

Bibtex

@article{df5fcd178f5d42819638bb1759e46b88,
title = "A Comparison of Endoscopic Ultrasound Guided Biopsy and Positron Emission Tomography with Integrated Computed Tomography in Lung Cancer Staging",
abstract = "BACKGROUND AND STUDY AIMS: Exact staging of patients with non-small-cell lung cancer (NSCLC) is important to improve selection of resectable and curable patients for surgery. Positron emission tomography with integrated computed tomography (PET/CT) and endoscopic ultrasound guided fine needle aspiration biopsy (EUS-FNA) are new and promising methods, but indications in lung cancer staging are controversial. Only few studies have compared the 2 methods. The aim of this study was to assess and compare the diagnostic values of PET/CT and EUS-FNA for diagnosing advanced lung cancer in patients, who had both procedures performed.PATIENTS AND METHODS: 27 patients considered to be potential candidates for resection of NSCLC underwent PET/CT and EUS-FNA. Diagnoses were confirmed either by open thoracotomy, mediastinoscopy or clinical follow-up. Advanced lung cancer was defined as tumour-stage ≥ IIIA(N2), corresponding to T4- and/or N2-N3- and/or M1 disease. Diagnostic values of PET/CT and EUS-FNA, with regard to the diagnosis of advanced lung cancer, were assessed and compared.RESULTS: The sensitivity of PET/CT and EUS-FNA were respectively 60{\%} and 60{\%} for T4 disease, 56{\%} versus 100{\%} for N2-N3 disease (p=0.12) and 100{\%} versus 33{\%} for M1 disease (p=0.50). For diagnosing advanced lung cancer PET/CT had a sensitivity of 79{\%}, specificity of 61{\%}, positive predictive value (PPV) of 69{\%}, negative predictive value (NPV) of 73{\%}, and an accuracy of 70{\%}. EUS-FNA had a sensitivity of 79{\%}, specificity of 100{\%}, PPV of 100{\%}, NPV of 81{\%}, and an accuracy of 89{\%} for advanced lung cancer.CONCLUSIONS: PET/CT and EUS-FNA had a comparable sensitivity and NPV for diagnosing advanced lung cancer, but EUS-FNA had superior specificity and PPV. The two methods seem to complement each other.",
author = "Larsen, {Stine Schmidt} and P Vilmann and K Krasnik and Asger Dirksen and P Clementsen and Skov, {Birgit G} and Jacobsen, {Grete Krag} and U Lassen and Annika Eigtved and Berthelsen, {Anne Kiil} and Jann Mortensen and Liselotte Hoejgaard",
year = "2009",
month = "1",
language = "English",
volume = "35",
pages = "5--12",
journal = "Current Health Sciences Journal",
issn = "2069-4032",
publisher = "Medical University Publishing House, Craiova",
number = "1",

}

RIS

TY - JOUR

T1 - A Comparison of Endoscopic Ultrasound Guided Biopsy and Positron Emission Tomography with Integrated Computed Tomography in Lung Cancer Staging

AU - Larsen, Stine Schmidt

AU - Vilmann, P

AU - Krasnik, K

AU - Dirksen, Asger

AU - Clementsen, P

AU - Skov, Birgit G

AU - Jacobsen, Grete Krag

AU - Lassen, U

AU - Eigtved, Annika

AU - Berthelsen, Anne Kiil

AU - Mortensen, Jann

AU - Hoejgaard, Liselotte

PY - 2009/1

Y1 - 2009/1

N2 - BACKGROUND AND STUDY AIMS: Exact staging of patients with non-small-cell lung cancer (NSCLC) is important to improve selection of resectable and curable patients for surgery. Positron emission tomography with integrated computed tomography (PET/CT) and endoscopic ultrasound guided fine needle aspiration biopsy (EUS-FNA) are new and promising methods, but indications in lung cancer staging are controversial. Only few studies have compared the 2 methods. The aim of this study was to assess and compare the diagnostic values of PET/CT and EUS-FNA for diagnosing advanced lung cancer in patients, who had both procedures performed.PATIENTS AND METHODS: 27 patients considered to be potential candidates for resection of NSCLC underwent PET/CT and EUS-FNA. Diagnoses were confirmed either by open thoracotomy, mediastinoscopy or clinical follow-up. Advanced lung cancer was defined as tumour-stage ≥ IIIA(N2), corresponding to T4- and/or N2-N3- and/or M1 disease. Diagnostic values of PET/CT and EUS-FNA, with regard to the diagnosis of advanced lung cancer, were assessed and compared.RESULTS: The sensitivity of PET/CT and EUS-FNA were respectively 60% and 60% for T4 disease, 56% versus 100% for N2-N3 disease (p=0.12) and 100% versus 33% for M1 disease (p=0.50). For diagnosing advanced lung cancer PET/CT had a sensitivity of 79%, specificity of 61%, positive predictive value (PPV) of 69%, negative predictive value (NPV) of 73%, and an accuracy of 70%. EUS-FNA had a sensitivity of 79%, specificity of 100%, PPV of 100%, NPV of 81%, and an accuracy of 89% for advanced lung cancer.CONCLUSIONS: PET/CT and EUS-FNA had a comparable sensitivity and NPV for diagnosing advanced lung cancer, but EUS-FNA had superior specificity and PPV. The two methods seem to complement each other.

AB - BACKGROUND AND STUDY AIMS: Exact staging of patients with non-small-cell lung cancer (NSCLC) is important to improve selection of resectable and curable patients for surgery. Positron emission tomography with integrated computed tomography (PET/CT) and endoscopic ultrasound guided fine needle aspiration biopsy (EUS-FNA) are new and promising methods, but indications in lung cancer staging are controversial. Only few studies have compared the 2 methods. The aim of this study was to assess and compare the diagnostic values of PET/CT and EUS-FNA for diagnosing advanced lung cancer in patients, who had both procedures performed.PATIENTS AND METHODS: 27 patients considered to be potential candidates for resection of NSCLC underwent PET/CT and EUS-FNA. Diagnoses were confirmed either by open thoracotomy, mediastinoscopy or clinical follow-up. Advanced lung cancer was defined as tumour-stage ≥ IIIA(N2), corresponding to T4- and/or N2-N3- and/or M1 disease. Diagnostic values of PET/CT and EUS-FNA, with regard to the diagnosis of advanced lung cancer, were assessed and compared.RESULTS: The sensitivity of PET/CT and EUS-FNA were respectively 60% and 60% for T4 disease, 56% versus 100% for N2-N3 disease (p=0.12) and 100% versus 33% for M1 disease (p=0.50). For diagnosing advanced lung cancer PET/CT had a sensitivity of 79%, specificity of 61%, positive predictive value (PPV) of 69%, negative predictive value (NPV) of 73%, and an accuracy of 70%. EUS-FNA had a sensitivity of 79%, specificity of 100%, PPV of 100%, NPV of 81%, and an accuracy of 89% for advanced lung cancer.CONCLUSIONS: PET/CT and EUS-FNA had a comparable sensitivity and NPV for diagnosing advanced lung cancer, but EUS-FNA had superior specificity and PPV. The two methods seem to complement each other.

M3 - Journal article

VL - 35

SP - 5

EP - 12

JO - Current Health Sciences Journal

JF - Current Health Sciences Journal

SN - 2069-4032

IS - 1

ER -

ID: 138426973