2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans

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Katrine B Hansen, Mette M Rosenkilde, Filip K Knop, Niels Wellner, Thi A Diep, Jens F Rehfeld, Ulrik B Andersen, Jens J Holst, Harald S. Hansen

Dietary fat is thought to stimulate release of incretin hormones via activation of fatty acid receptors in the intestine. However, dietary fat (triacylglycerol) is digested to 2-monoacylglycerol and fatty acids. Activation of G protein-coupled receptor 119 (GPR119) stimulates glucagon-like peptide-1 (GLP-1) release from the intestinal L-cells. We aimed to investigate if 2-oleoyl glycerol (2OG) can activate GPR119 in vitro and stimulate GLP-1 secretion in vivo.
OriginalsprogEngelsk
TidsskriftJournal of Clinical Endocrinology and Metabolism
Vol/bind96
Udgave nummer9
Sider (fra-til)E1409-17
ISSN0021-972X
DOI
StatusUdgivet - 2011

ID: 36082144