1,2,3-triazolyl amino acids as AMPA receptor ligands

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Nathan J. Stanley, Daniel Sejer Pedersen, Birgitte Nielsen, Trine Kvist, Jesper M Mathiesen, Hans Bräuner-Osborne, Dennis K Taylor, Andrew D Abell

The central nervous system glutamate receptors are an important target for drug discovery. Herein we report initial investigations into the synthesis and glutamate receptor activity of 1,2,3-triazolyl amino acids. Two compounds were found to be selective AMPA receptor ligands, which warrant further investigation.
OriginalsprogEngelsk
TidsskriftBioorganic & Medicinal Chemistry Letters
Vol/bind20
Udgave nummer24
Sider (fra-til)7512-7515
ISSN0960-894X
DOI
StatusUdgivet - 15 dec. 2010

ID: 32132476