Stine Harloff-Helleberg

Stine Harloff-Helleberg

Adjunkt

Stine is Postdoc at Section for Biologics at the Department of Pharmacy, University of Copenhagen. She holds a Master in Pharmaceutical Sciences from University of Copenhagen and a PhD in food biophysics from the Faculty of Science, University of Copenhagen.

For the last 7 years, Stine has been working in academia including both research in close collaboration with the industry (Arla during the PhD and as an external Novo Nordisk fellow during her postdoc), lecturing and supervision of especially master students. Also, she has developed teaching material for Development of teaching material to the European Patients' Academy Expert Training Course for Patients and Patient Representatives (EUPATI) on the Medicines Research & Development Process.

Based on a master project at LEO Pharma focusing on cutaneous drug delivery of small molecules including use of ex vivo skin models, her PhD was within physico-chemical characterization of fat-based emulsions including utilization of large synchrotron facilities. With this interdisciplinary background, Stine moved on to a postdoc in the field of oral delivery of large molecules, especially focusing on in vitro and in vivo evaluation hereof. During her PhD, she extensively used advanced physical and biophysical analytical, all highly applicable to development and characterization of the physico-chemical behavior of drug delivery systems (DDS). Stine’s current work includes development of DDS primarily being hydrogels including permeation enhancers such as lipids, membrane modulating peptides and cell penetrating peptides. The work is with a particular focus on a detailed understanding of the physico-chemical structure of DDS is key to fully to understand their mechanistic behavior in vitro and in vivo. Also, focus is on the mechanistic behavior, safety, kinetics and dynamics of the DDS has subsequently been studied using advanced in vitro models and in complex in vivo models.

Stine is currently associated to employed on an EU project, COMPACT, where she is Project leader and responsible for in vitro and in vivo methodology. In relation to this, she holds of an in vivo license which includes monitoring and approval of protocols used under the license, quality assurance of the technical skills of the people working under the license, assurance of ethical aspects in agreement with both legislation and license, yearly reporting to the Animal Experiments Inspectorate, The Ministry of Environment and Food of Denmark.

Udvalgte publikationer

  1. Udgivet

    Cell-penetrating peptides as carriers for transepithelial drug delivery in vitro

    Rønholt, S., Kristensen, M. & Nielsen, H. M., 2015, Cell-penetrating peptides : Methods and Protocols. Langel, Ü. (red.). Bind 1324. s. 261-277 17 s.

    Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiForskningfagfællebedømt

  2. Udgivet

    The effect of butter grains on physical properties of butter-like emulsions

    Rønholt, S., Buldo, P., Mortensen, K., Andersen, U., Knudsen, J. C. & Wiking, L., 2014, I : Journal of Dairy Science. 97, 4, s. 1929-1938 10 s.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  3. Udgivet

    Metodeudvikling: Reologi til bestemmelse af fedtbaserede produkters materialeegenskaber

    Rønholt, S., Knudsen, J. C. & Mortensen, K., 2013, I : Dansk Kemi. 94, 11, s. 33-34 2 s.

    Publikation: Bidrag til tidsskriftTidsskriftartikelFormidling

  4. Udgivet

    Fat crystallization in dairy products: Rheology and microstructure of fat crystals

    Rønholt, S., 2013, Department of Food Science, University of Copenhagen. 283 s.

    Publikation: Bog/antologi/afhandling/rapportPh.d.-afhandlingForskning

  5. Udgivet

    Effect of cream cooling rate and water content on butter microstructure during four weeks of storage

    Rønholt, S., Kirkensgaard, J. J. K., Mortensen, K. & Knudsen, J. C., 2014, I : Food Hydrocolloids. 34, s. 169-176 8 s.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  6. Udgivet

    The effect of capacity, rotational speed and storage on crystallization and rheological properties of puff pastry butter

    Rønholt, S., Kirkensgaard, J. J. K., Høyer, K. F., Mortensen, K. & Knudsen, J. C., 2014, I : Journal of the American Oil Chemists' Society. 91, 1, s. 29-38

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  7. Udgivet

    The effective factors on the structure of butter and other milk fat-based products

    Rønholt, S., Mortensen, K. & Knudsen, J. C., 2013, I : Comprehensive Reviews in Food Science and Food Safety. 12, 5, s. 468-482 15 s.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  8. Udgivet

    Small deformation rheology for characterization of anhydrous milk fat/rapeseed oil samples

    Rønholt, S., Mortensen, K. & Knudsen, J. C., 2014, I : Journal of Texture Studies. 45, 1, s. 20-29 10 s.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  9. Udgivet

    Polymorphism, microstructure and rheology of butter. Effects of cream heat treatment

    Rønholt, S., Kirkensgaard, J. J. K., Pedersen, T. B., Mortensen, K. & Knudsen, J. C., 2012, I : Food Chemistry. 135, 3, s. 1730-1739 10 s.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  10. Udgivet

    Microstructural and rheological characterization of fat crystals

    Rønholt, S., Mortensen, K., Hassenkam, T. & Knudsen, J. C., 2010. 1 s.

    Publikation: KonferencebidragPosterForskning

  11. Udgivet

    Calcipotriol delivery into the skin with PEGylated liposomes

    Knudsen, N. Ø., Rønholt, S., Salte, R. D., Jorgensen, L., Thormann, T., Basse, L. H., Hansen, J., Frokjaer, S. & Foged, C., 2012, I : European Journal of Pharmaceutics and Biopharmaceutics. 81, 3, s. 532-9 8 s.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  12. Udgivet

    Lipid-protein interactions in nanodiscs: how to enhance stability

    Wadsäter, M. H., Cardenas Gomez, M., Rønholt, S., Maric, S., Skar-Gislinge, N., Midtgaard, S. R., Arleth, L., Mortensen, K., Ryan, R. O. & Simonsen, J. B., 2012, I : Biophysical Journal. 102, 3, s. 236a 1 s.

    Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningfagfællebedømt

  13. Udgivet

    Fedtstruktur: innovation af smør og blandingsprodukter

    Rønholt, S., Knudsen, J. C., Mortensen, K., Kaufmann, N., Buldo, P., Wiking, L. & Andersen, U., 2012, I : Maelkeritidende. 6, s. 8-9 2 s.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

  14. Udgivet

    Danmark kan lære meget af australske erfaringer med klinisk farmaci

    Rønholt, S., 2008, I : Pharma. 7, s. 32-34 3 s.

    Publikation: Bidrag til tidsskriftTidsskriftartikelFormidling

Udvalgte aktiviteter

  1. 2014 AAPS Annual meeting and EXPO

    Stine Rønholt (Taler)
    2 nov. 20146 nov. 2014

    Aktivitet: Deltagelse i eller arrangement af en begivenhed - typerDeltagelse i workshop, seminar og kursus

  2. COMPACT

    Stine Rønholt (Taler)
    3 feb. 20155 feb. 2015

    Aktivitet: Deltagelse i eller arrangement af en begivenhed - typerDeltagelse i workshop, seminar og kursus

  3. EUPATI

    Stine Rønholt (Taler)
    1 jan. 2014 → …

    Aktivitet: Deltagelse i eller arrangement af en begivenhed - typerDeltagelse i workshop, seminar og kursus

  4. Cell Penetrating Peptides

    Stine Rønholt (Deltager)
    7 okt. 201313 okt. 2013

    Aktivitet: Deltagelse i eller arrangement af en begivenhed - typerDeltagelse i workshop, seminar og kursus

ID: 18182987