Protein Signaling Program
Blegdamsvej 3, 2200 København N, Bygning 6, Bygning: 06-1-20
Jiri Lukas studies protein pathways that orchestrate spatial and temporal dynamics of chromosomes during the mammalian cell cycle and after DNA damage, with an emphasis on how are these mechanisms subverted in cancer and other diseases associated with unstable genomes. His long-term interests include high-content microscopy screens for genome caretakers and real-time imaging of signaling and repair proteins.
Recent discoveries from Jiri’s lab include:
• Ubiquitin-driven signalling pathways that barcode chromatin near the DNA lesions to assemble repair and signaling proteins
• Heritability of chromosomal lesions generated on unreplicated DNA during mitosis
• The concept of rate imitation of nodal signaling components as a mechanism to confine repair reactions and posttranslational chromatin modifications to damaged loci in the genome