Jan-Michael Kugler
Lektor
Morphogenesis and Differentiation Program
Panum, Bygning: 18.4.48
2200 København N
Medlem af:
Primære forskningsområder
I am broadly interested in the molecular and cellular mechanisms that leads to malignant transformation of cancer cells. I am using an invertebrate model organism – the fruit fly Drosophila – as a discovery platform to identify novel genes involved in metastasis development. I am using mammalian cell culture models to explore whether the function of candidate genes may be conserved and hence potentially relevant to human cancers.
Aktuel forskning
Currently, I am investigating ubiquitin-dependent regulation of a well-known tumor suppressor gene by a de-ubiquitinating enzyme. Moreover, I am investigating a novel metabolic enzyme whose depletion causes cancer-like phenotypes both in the fly and in cultured human cells.
ID: 45429530
Flest downloads
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172
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DUB3 Deubiquitylating Enzymes Regulate Hippo Pathway Activity by Regulating the Stability of ITCH, LATS and AMOT Proteins
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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64
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USP21 regulates Hippo pathway activity by mediating MARK protein turnover
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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49
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Metabolic control of PPAR activity by aldehyde dehydrogenase regulates invasive cell behavior and predicts survival in hepatocellular and renal clear cell carcinoma
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Udgivet