Elisabeth Marianne Bock
Laboratorium for Neural Plasticitet
2200 København N
InteresseområderElisabeth Bock focuses on the role of cell adhesion molecules in neural plasticity and cognition under normal and neurodegenerative conditions. Methodologies encompass a broad range of approaches and techniques, from determination of atomic structure of protein modules employing nuclear magnetic resonance (NMR) spectroscopy and X-ray crystallography, computer modelling of inter- and intramolecular interactions, in vitro models of differentiation, survival and presynaptic function of primary neurons, surface plasmon resonance analysis of protein interaction and electrophysiology to in vivo models of learning and memory, Alzheimer's disease, Huntington's disease, traumatic brain injury and schizophrenia including the use of transgenic animals. A variety of neural cell adhesion molecules involved in synapse formation and synaptic plasticity, such as NCAM, L1, nectins, synCAM and other necls, neurexins, neuroligins, ephrins and ephrin receptors, their adhesion mechanisms, interactions with other molecules and signalling mechanisms are in focus. Adhesion molecules are considered to be important pharmaceutical targets, and knowledge of the structural basis of their interactions and binding sites is used for the identification of small molecules, peptides, mimicking various aspects of adhesion molecule functions. Mimetic peptides are also used as suitable pharmacological tools to study adhesion molecule-induced signal transduction mechanisms in in vitro models and the role of adhesion molecules in impaired neural plasticity employing animal models of neurodegenerative disorders.