Serum levels of perfluorinated compounds and sperm Y:X chromosome ratio in two European populations and in Inuit from Greenland

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Serum levels of perfluorinated compounds and sperm Y:X chromosome ratio in two European populations and in Inuit from Greenland. / Kvist, Linus; Giwercman, Yvonne Lundberg; Jönsson, Bo A G; Lindh, Christian H; Toft, Gunnar; Strucinski, Pawel; Pedersen, Henning S; Zvyezday, Valentyna; Giwercman, Aleksander; Bonde, Jens Peter Ellekilde.

In: Reproductive Toxicology, Vol. 34, No. 4, 2012, p. 644-50.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kvist, L, Giwercman, YL, Jönsson, BAG, Lindh, CH, Toft, G, Strucinski, P, Pedersen, HS, Zvyezday, V, Giwercman, A & Bonde, JPE 2012, 'Serum levels of perfluorinated compounds and sperm Y:X chromosome ratio in two European populations and in Inuit from Greenland', Reproductive Toxicology, vol. 34, no. 4, pp. 644-50. https://doi.org/10.1016/j.reprotox.2012.09.007

APA

Kvist, L., Giwercman, Y. L., Jönsson, B. A. G., Lindh, C. H., Toft, G., Strucinski, P., Pedersen, H. S., Zvyezday, V., Giwercman, A., & Bonde, J. P. E. (2012). Serum levels of perfluorinated compounds and sperm Y:X chromosome ratio in two European populations and in Inuit from Greenland. Reproductive Toxicology, 34(4), 644-50. https://doi.org/10.1016/j.reprotox.2012.09.007

Vancouver

Kvist L, Giwercman YL, Jönsson BAG, Lindh CH, Toft G, Strucinski P et al. Serum levels of perfluorinated compounds and sperm Y:X chromosome ratio in two European populations and in Inuit from Greenland. Reproductive Toxicology. 2012;34(4):644-50. https://doi.org/10.1016/j.reprotox.2012.09.007

Author

Kvist, Linus ; Giwercman, Yvonne Lundberg ; Jönsson, Bo A G ; Lindh, Christian H ; Toft, Gunnar ; Strucinski, Pawel ; Pedersen, Henning S ; Zvyezday, Valentyna ; Giwercman, Aleksander ; Bonde, Jens Peter Ellekilde. / Serum levels of perfluorinated compounds and sperm Y:X chromosome ratio in two European populations and in Inuit from Greenland. In: Reproductive Toxicology. 2012 ; Vol. 34, No. 4. pp. 644-50.

Bibtex

@article{9ace44bac7bf48f5a191dff4e6ab7bd5,
title = "Serum levels of perfluorinated compounds and sperm Y:X chromosome ratio in two European populations and in Inuit from Greenland",
abstract = "This study investigated whether perfluorooctanoic acid (PFOA) and perfluorooctanesulfonate (PFOS), which exhibit reproductive toxicity in experimental animals, affect sperm sex chromosome ratio. The Y:X ratio was determined by fluorescence in situ hybridization. Serum concentrations of PFOA and PFOS were measured in 607 men from Greenland, Poland and Ukraine using liquid chromatography-tandem mass spectrometry. Data was analyzed by linear and nonlinear regression. We observed no associations between PFOA and Y:X ratio (p=0.845 in a linear model, p=0.296 in a nonlinear model). A positive nonlinear association between PFOS and Y:X ratio was observed (p=0.016), with no association in a linear model (p=0.118). Analyzing the populations separately, a negative trend between categorized PFOS exposure and Y:X ratio was observed for the Inuit (B=-0.002, p=0.044). In conclusion, there was a negative trend between Y:X ratio and PFOS in the Inuit, while there was no association between PFOA and the Y:X ratio in adult men.",
author = "Linus Kvist and Giwercman, {Yvonne Lundberg} and J{\"o}nsson, {Bo A G} and Lindh, {Christian H} and Gunnar Toft and Pawel Strucinski and Pedersen, {Henning S} and Valentyna Zvyezday and Aleksander Giwercman and Bonde, {Jens Peter Ellekilde}",
note = "Copyright {\textcopyright} 2012 Elsevier Inc. All rights reserved.",
year = "2012",
doi = "10.1016/j.reprotox.2012.09.007",
language = "English",
volume = "34",
pages = "644--50",
journal = "Reproductive Toxicology",
issn = "0890-6238",
publisher = "Elsevier",
number = "4",

}

RIS

TY - JOUR

T1 - Serum levels of perfluorinated compounds and sperm Y:X chromosome ratio in two European populations and in Inuit from Greenland

AU - Kvist, Linus

AU - Giwercman, Yvonne Lundberg

AU - Jönsson, Bo A G

AU - Lindh, Christian H

AU - Toft, Gunnar

AU - Strucinski, Pawel

AU - Pedersen, Henning S

AU - Zvyezday, Valentyna

AU - Giwercman, Aleksander

AU - Bonde, Jens Peter Ellekilde

N1 - Copyright © 2012 Elsevier Inc. All rights reserved.

PY - 2012

Y1 - 2012

N2 - This study investigated whether perfluorooctanoic acid (PFOA) and perfluorooctanesulfonate (PFOS), which exhibit reproductive toxicity in experimental animals, affect sperm sex chromosome ratio. The Y:X ratio was determined by fluorescence in situ hybridization. Serum concentrations of PFOA and PFOS were measured in 607 men from Greenland, Poland and Ukraine using liquid chromatography-tandem mass spectrometry. Data was analyzed by linear and nonlinear regression. We observed no associations between PFOA and Y:X ratio (p=0.845 in a linear model, p=0.296 in a nonlinear model). A positive nonlinear association between PFOS and Y:X ratio was observed (p=0.016), with no association in a linear model (p=0.118). Analyzing the populations separately, a negative trend between categorized PFOS exposure and Y:X ratio was observed for the Inuit (B=-0.002, p=0.044). In conclusion, there was a negative trend between Y:X ratio and PFOS in the Inuit, while there was no association between PFOA and the Y:X ratio in adult men.

AB - This study investigated whether perfluorooctanoic acid (PFOA) and perfluorooctanesulfonate (PFOS), which exhibit reproductive toxicity in experimental animals, affect sperm sex chromosome ratio. The Y:X ratio was determined by fluorescence in situ hybridization. Serum concentrations of PFOA and PFOS were measured in 607 men from Greenland, Poland and Ukraine using liquid chromatography-tandem mass spectrometry. Data was analyzed by linear and nonlinear regression. We observed no associations between PFOA and Y:X ratio (p=0.845 in a linear model, p=0.296 in a nonlinear model). A positive nonlinear association between PFOS and Y:X ratio was observed (p=0.016), with no association in a linear model (p=0.118). Analyzing the populations separately, a negative trend between categorized PFOS exposure and Y:X ratio was observed for the Inuit (B=-0.002, p=0.044). In conclusion, there was a negative trend between Y:X ratio and PFOS in the Inuit, while there was no association between PFOA and the Y:X ratio in adult men.

U2 - 10.1016/j.reprotox.2012.09.007

DO - 10.1016/j.reprotox.2012.09.007

M3 - Journal article

C2 - 23044208

VL - 34

SP - 644

EP - 650

JO - Reproductive Toxicology

JF - Reproductive Toxicology

SN - 0890-6238

IS - 4

ER -

ID: 48432142