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Genome-wide association studies identify four ER negative-specific breast cancer risk loci. / Garcia-Closas, Montserrat; Couch, Fergus J; Lindstrom, Sara; Michailidou, Kyriaki; Schmidt, Marjanka K; Brook, Mark N; Orr, Nick; Rhie, Suhn Kyong; Riboli, Elio; Feigelson, Heather S; Le Marchand, Loic; Buring, Julie E; Eccles, Diana; Miron, Penelope; Fasching, Peter A; Brauch, Hiltrud; Chang-Claude, Jenny; Carpenter, Jane; Godwin, Andrew K; Nevanlinna, Heli; Giles, Graham G; Cox, Angela; Hopper, John L; Bolla, Manjeet K; Wang, Qin; Dennis, Joe; Dicks, Ed; Howat, Will J; Schoof, Nils; Bojesen, Stig E; Lambrechts, Diether; Broeks, Annegien; Andrulis, Irene L; Guénel, Pascal; Burwinkel, Barbara; Sawyer, Elinor J; Hollestelle, Antoinette; Fletcher, Olivia; Winqvist, Robert; Brenner, Hermann; Mannermaa, Arto; Hamann, Ute; Meindl, Alfons; Lindblom, Annika; Zheng, Wei; Devillee, Peter; Goldberg, Mark S; Lubinski, Jan; Kristensen, Vessela; Nordestgaard, Børge G; Gene ENvironmental Interaction and breast CAncer (GENICA) Network.
In:
Nature Genetics, Vol. 45, No. 4, 04.2013, p. 392-8, 398e1-2.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Garcia-Closas, M, Couch, FJ, Lindstrom, S, Michailidou, K, Schmidt, MK, Brook, MN, Orr, N, Rhie, SK, Riboli, E, Feigelson, HS, Le Marchand, L, Buring, JE, Eccles, D, Miron, P, Fasching, PA, Brauch, H, Chang-Claude, J, Carpenter, J, Godwin, AK, Nevanlinna, H, Giles, GG, Cox, A, Hopper, JL, Bolla, MK, Wang, Q, Dennis, J, Dicks, E, Howat, WJ, Schoof, N, Bojesen, SE, Lambrechts, D, Broeks, A, Andrulis, IL, Guénel, P, Burwinkel, B, Sawyer, EJ, Hollestelle, A, Fletcher, O, Winqvist, R, Brenner, H, Mannermaa, A, Hamann, U, Meindl, A, Lindblom, A, Zheng, W, Devillee, P, Goldberg, MS, Lubinski, J, Kristensen, V
, Nordestgaard, BG & Gene ENvironmental Interaction and breast CAncer (GENICA) Network 2013, '
Genome-wide association studies identify four ER negative-specific breast cancer risk loci',
Nature Genetics, vol. 45, no. 4, pp. 392-8, 398e1-2.
https://doi.org/10.1038/ng.2561APA
Garcia-Closas, M., Couch, F. J., Lindstrom, S., Michailidou, K., Schmidt, M. K., Brook, M. N., Orr, N., Rhie, S. K., Riboli, E., Feigelson, H. S., Le Marchand, L., Buring, J. E., Eccles, D., Miron, P., Fasching, P. A., Brauch, H., Chang-Claude, J., Carpenter, J., Godwin, A. K., ... Gene ENvironmental Interaction and breast CAncer (GENICA) Network (2013).
Genome-wide association studies identify four ER negative-specific breast cancer risk loci.
Nature Genetics,
45(4), 392-8, 398e1-2.
https://doi.org/10.1038/ng.2561Vancouver
Garcia-Closas M, Couch FJ, Lindstrom S, Michailidou K, Schmidt MK, Brook MN et al.
Genome-wide association studies identify four ER negative-specific breast cancer risk loci.
Nature Genetics. 2013 Apr;45(4):392-8, 398e1-2.
https://doi.org/10.1038/ng.2561Author
Garcia-Closas, Montserrat ; Couch, Fergus J ; Lindstrom, Sara ; Michailidou, Kyriaki ; Schmidt, Marjanka K ; Brook, Mark N ; Orr, Nick ; Rhie, Suhn Kyong ; Riboli, Elio ; Feigelson, Heather S ; Le Marchand, Loic ; Buring, Julie E ; Eccles, Diana ; Miron, Penelope ; Fasching, Peter A ; Brauch, Hiltrud ; Chang-Claude, Jenny ; Carpenter, Jane ; Godwin, Andrew K ; Nevanlinna, Heli ; Giles, Graham G ; Cox, Angela ; Hopper, John L ; Bolla, Manjeet K ; Wang, Qin ; Dennis, Joe ; Dicks, Ed ; Howat, Will J ; Schoof, Nils ; Bojesen, Stig E ; Lambrechts, Diether ; Broeks, Annegien ; Andrulis, Irene L ; Guénel, Pascal ; Burwinkel, Barbara ; Sawyer, Elinor J ; Hollestelle, Antoinette ; Fletcher, Olivia ; Winqvist, Robert ; Brenner, Hermann ; Mannermaa, Arto ; Hamann, Ute ; Meindl, Alfons ; Lindblom, Annika ; Zheng, Wei ; Devillee, Peter ; Goldberg, Mark S ; Lubinski, Jan ; Kristensen, Vessela ; Nordestgaard, Børge G ; Gene ENvironmental Interaction and breast CAncer (GENICA) Network. / Genome-wide association studies identify four ER negative-specific breast cancer risk loci. In: Nature Genetics. 2013 ; Vol. 45, No. 4. pp. 392-8, 398e1-2.
Bibtex
@article{bfe5b9d471a04f5d986c3be6e93d5644,
title = "Genome-wide association studies identify four ER negative-specific breast cancer risk loci",
abstract = "Estrogen receptor (ER)-negative tumors represent 20-30% of all breast cancers, with a higher proportion occurring in younger women and women of African ancestry. The etiology and clinical behavior of ER-negative tumors are different from those of tumors expressing ER (ER positive), including differences in genetic predisposition. To identify susceptibility loci specific to ER-negative disease, we combined in a meta-analysis 3 genome-wide association studies of 4,193 ER-negative breast cancer cases and 35,194 controls with a series of 40 follow-up studies (6,514 cases and 41,455 controls), genotyped using a custom Illumina array, iCOGS, developed by the Collaborative Oncological Gene-environment Study (COGS). SNPs at four loci, 1q32.1 (MDM4, P = 2.1 × 10(-12) and LGR6, P = 1.4 × 10(-8)), 2p24.1 (P = 4.6 × 10(-8)) and 16q12.2 (FTO, P = 4.0 × 10(-8)), were associated with ER-negative but not ER-positive breast cancer (P > 0.05). These findings provide further evidence for distinct etiological pathways associated with invasive ER-positive and ER-negative breast cancers.",
author = "Montserrat Garcia-Closas and Couch, {Fergus J} and Sara Lindstrom and Kyriaki Michailidou and Schmidt, {Marjanka K} and Brook, {Mark N} and Nick Orr and Rhie, {Suhn Kyong} and Elio Riboli and Feigelson, {Heather S} and {Le Marchand}, Loic and Buring, {Julie E} and Diana Eccles and Penelope Miron and Fasching, {Peter A} and Hiltrud Brauch and Jenny Chang-Claude and Jane Carpenter and Godwin, {Andrew K} and Heli Nevanlinna and Giles, {Graham G} and Angela Cox and Hopper, {John L} and Bolla, {Manjeet K} and Qin Wang and Joe Dennis and Ed Dicks and Howat, {Will J} and Nils Schoof and Bojesen, {Stig E} and Diether Lambrechts and Annegien Broeks and Andrulis, {Irene L} and Pascal Gu{\'e}nel and Barbara Burwinkel and Sawyer, {Elinor J} and Antoinette Hollestelle and Olivia Fletcher and Robert Winqvist and Hermann Brenner and Arto Mannermaa and Ute Hamann and Alfons Meindl and Annika Lindblom and Wei Zheng and Peter Devillee and Goldberg, {Mark S} and Jan Lubinski and Vessela Kristensen and Nordestgaard, {B{\o}rge G} and B{\o}rge Nordestgaard",
year = "2013",
month = apr,
doi = "10.1038/ng.2561",
language = "English",
volume = "45",
pages = "392--8, 398e1--2",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
number = "4",
}
RIS
TY - JOUR
T1 - Genome-wide association studies identify four ER negative-specific breast cancer risk loci
AU - Garcia-Closas, Montserrat
AU - Couch, Fergus J
AU - Lindstrom, Sara
AU - Michailidou, Kyriaki
AU - Schmidt, Marjanka K
AU - Brook, Mark N
AU - Orr, Nick
AU - Rhie, Suhn Kyong
AU - Riboli, Elio
AU - Feigelson, Heather S
AU - Le Marchand, Loic
AU - Buring, Julie E
AU - Eccles, Diana
AU - Miron, Penelope
AU - Fasching, Peter A
AU - Brauch, Hiltrud
AU - Chang-Claude, Jenny
AU - Carpenter, Jane
AU - Godwin, Andrew K
AU - Nevanlinna, Heli
AU - Giles, Graham G
AU - Cox, Angela
AU - Hopper, John L
AU - Bolla, Manjeet K
AU - Wang, Qin
AU - Dennis, Joe
AU - Dicks, Ed
AU - Howat, Will J
AU - Schoof, Nils
AU - Bojesen, Stig E
AU - Lambrechts, Diether
AU - Broeks, Annegien
AU - Andrulis, Irene L
AU - Guénel, Pascal
AU - Burwinkel, Barbara
AU - Sawyer, Elinor J
AU - Hollestelle, Antoinette
AU - Fletcher, Olivia
AU - Winqvist, Robert
AU - Brenner, Hermann
AU - Mannermaa, Arto
AU - Hamann, Ute
AU - Meindl, Alfons
AU - Lindblom, Annika
AU - Zheng, Wei
AU - Devillee, Peter
AU - Goldberg, Mark S
AU - Lubinski, Jan
AU - Kristensen, Vessela
AU - Nordestgaard, Børge G
AU - Gene ENvironmental Interaction and breast CAncer (GENICA) Network
PY - 2013/4
Y1 - 2013/4
N2 - Estrogen receptor (ER)-negative tumors represent 20-30% of all breast cancers, with a higher proportion occurring in younger women and women of African ancestry. The etiology and clinical behavior of ER-negative tumors are different from those of tumors expressing ER (ER positive), including differences in genetic predisposition. To identify susceptibility loci specific to ER-negative disease, we combined in a meta-analysis 3 genome-wide association studies of 4,193 ER-negative breast cancer cases and 35,194 controls with a series of 40 follow-up studies (6,514 cases and 41,455 controls), genotyped using a custom Illumina array, iCOGS, developed by the Collaborative Oncological Gene-environment Study (COGS). SNPs at four loci, 1q32.1 (MDM4, P = 2.1 × 10(-12) and LGR6, P = 1.4 × 10(-8)), 2p24.1 (P = 4.6 × 10(-8)) and 16q12.2 (FTO, P = 4.0 × 10(-8)), were associated with ER-negative but not ER-positive breast cancer (P > 0.05). These findings provide further evidence for distinct etiological pathways associated with invasive ER-positive and ER-negative breast cancers.
AB - Estrogen receptor (ER)-negative tumors represent 20-30% of all breast cancers, with a higher proportion occurring in younger women and women of African ancestry. The etiology and clinical behavior of ER-negative tumors are different from those of tumors expressing ER (ER positive), including differences in genetic predisposition. To identify susceptibility loci specific to ER-negative disease, we combined in a meta-analysis 3 genome-wide association studies of 4,193 ER-negative breast cancer cases and 35,194 controls with a series of 40 follow-up studies (6,514 cases and 41,455 controls), genotyped using a custom Illumina array, iCOGS, developed by the Collaborative Oncological Gene-environment Study (COGS). SNPs at four loci, 1q32.1 (MDM4, P = 2.1 × 10(-12) and LGR6, P = 1.4 × 10(-8)), 2p24.1 (P = 4.6 × 10(-8)) and 16q12.2 (FTO, P = 4.0 × 10(-8)), were associated with ER-negative but not ER-positive breast cancer (P > 0.05). These findings provide further evidence for distinct etiological pathways associated with invasive ER-positive and ER-negative breast cancers.
U2 - 10.1038/ng.2561
DO - 10.1038/ng.2561
M3 - Journal article
C2 - 23535733
VL - 45
SP - 392-8, 398e1-2
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 4
ER -
