Development and validation of an MRI reference criterion for defining a positive SIJ MRI in spondyloarthritis
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Development and validation of an MRI reference criterion for defining a positive SIJ MRI in spondyloarthritis. / Weber, Ulrich; Zubler, Veronika; Pedersen, Susanne J; Rufibach, Kaspar; Lambert, Robert G W; Chan, Stanley M; Østergaard, Mikkel; Maksymowych, Walter P.
In: Arthritis Care and Research, 2012.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Development and validation of an MRI reference criterion for defining a positive SIJ MRI in spondyloarthritis
AU - Weber, Ulrich
AU - Zubler, Veronika
AU - Pedersen, Susanne J
AU - Rufibach, Kaspar
AU - Lambert, Robert G W
AU - Chan, Stanley M
AU - Østergaard, Mikkel
AU - Maksymowych, Walter P
N1 - Copyright © 2012 by the American College of Rheumatology.
PY - 2012
Y1 - 2012
N2 - OBJECTIVE: To validate an MRI reference criterion for a positive SIJ MRI based on the level of confidence in classification of spondyloarthritis (SpA) by expert MRI readers. METHODS: Four readers assessed SIJ MRI in two inception cohorts (A/B) of 157 consecutive back pain patients ≤50 years, and in 20 healthy controls. Patients were classified according to clinical examination and pelvic radiography as having non-radiographic axial SpA (n=51), ankylosing spondylitis (n=34), or non-specific back pain (n=72). Readers recorded their level of confidence in the classification of SpA on a 0-10 scale (0=definitely not; 10=definite). The MRI reference criterion was pre-specified as the majority of readers recording a confidence of 8-10; absence of SpA required all readers to record Non-SpA (confidence 0-4). We calculated inter-reader reliability and agreement between MRI-based and clinical classification using kappa statistics. We estimated cut-off values for MRI lesions attaining specificity `0.90 for SpA. RESULTS: 76.4%/71.6% of subjects in cohorts A/B met the MRI criterion. Kappa values for inter-reader agreement were 0.76/0.80, and between MRI-based and clinical assessment 0.93/0.57. Using this MRI reference criterion, the cut-off for number of affected SIJ quadrants needed to reach a pre-defined specificity `0.90 was `2/`2 for BME and `1/`1 for erosion in cohorts A/B, and both lesions BME and/or erosion increased sensitivity without reducing specificity. CONCLUSION: This data-driven study using two inception cohorts and comparing clinical and MRI-based classification supports the case for including both erosion and BME to define a positive SIJ MRI for the classification of axial SpA. © 2012 by the American College of Rheumatology.
AB - OBJECTIVE: To validate an MRI reference criterion for a positive SIJ MRI based on the level of confidence in classification of spondyloarthritis (SpA) by expert MRI readers. METHODS: Four readers assessed SIJ MRI in two inception cohorts (A/B) of 157 consecutive back pain patients ≤50 years, and in 20 healthy controls. Patients were classified according to clinical examination and pelvic radiography as having non-radiographic axial SpA (n=51), ankylosing spondylitis (n=34), or non-specific back pain (n=72). Readers recorded their level of confidence in the classification of SpA on a 0-10 scale (0=definitely not; 10=definite). The MRI reference criterion was pre-specified as the majority of readers recording a confidence of 8-10; absence of SpA required all readers to record Non-SpA (confidence 0-4). We calculated inter-reader reliability and agreement between MRI-based and clinical classification using kappa statistics. We estimated cut-off values for MRI lesions attaining specificity `0.90 for SpA. RESULTS: 76.4%/71.6% of subjects in cohorts A/B met the MRI criterion. Kappa values for inter-reader agreement were 0.76/0.80, and between MRI-based and clinical assessment 0.93/0.57. Using this MRI reference criterion, the cut-off for number of affected SIJ quadrants needed to reach a pre-defined specificity `0.90 was `2/`2 for BME and `1/`1 for erosion in cohorts A/B, and both lesions BME and/or erosion increased sensitivity without reducing specificity. CONCLUSION: This data-driven study using two inception cohorts and comparing clinical and MRI-based classification supports the case for including both erosion and BME to define a positive SIJ MRI for the classification of axial SpA. © 2012 by the American College of Rheumatology.
U2 - 10.1002/acr.21893
DO - 10.1002/acr.21893
M3 - Journal article
C2 - 23203670
JO - Arthritis care and research : the official journal of the Arthritis Health Professions Association
JF - Arthritis care and research : the official journal of the Arthritis Health Professions Association
SN - 0893-7524
ER -
ID: 48616077