Young men with low birthweight exhibit decreased plasticity of genome-wide muscle DNA methylation by high-fat overfeeding
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The association between low birthweight (LBW) and risk of developing type 2 diabetes may involve epigenetic mechanisms, with skeletal muscle being a prime target tissue. Differential DNA methylation patterns have been observed in single genes in muscle tissue from type 2 diabetic and LBW individuals, and we recently showed multiple DNA methylation changes during short-term high-fat overfeeding in muscle of healthy people. In a randomised crossover study, we analysed genome-wide DNA promoter methylation in skeletal muscle of 17 young LBW men and 23 matched normal birthweight (NBW) men after a control and a 5 day high-fat overfeeding diet.
Originalsprog | Engelsk |
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Tidsskrift | Diabetologia |
Vol/bind | 57 |
Udgave nummer | 6 |
Sider (fra-til) | 1154-1158 |
Antal sider | 5 |
ISSN | 0012-186X |
DOI | |
Status | Udgivet - 26 feb. 2014 |
ID: 102065681