Online monitoring of urea concentration in dialysate with dual-beam Fourier-transform near-infrared spectroscopy
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
The robustness of a dual-beam, optical null, Fouriertransform near-infrared (FTNIR) spectrometer was investigated by, means of online, near-infrared measurements and predictions of urea concentrations in spent dialysate during hemodialysis treatment. Simple multivariate calibration using a few factors based on a small number of prepared samples provided stable and accurate predictions over a period of 1 month. The calibration was robust when faced with adjustment of reference cell intensity and did not require a daily measured reference spectrum. The root-mean-square error of prediction of urea was 0.4 mM based on a two-factor partial least-squares regression model.
Originalsprog | Engelsk |
---|---|
Tidsskrift | Journal of Biomedical Optics |
Vol/bind | 9 |
Udgave nummer | 3 |
Sider (fra-til) | 553-557 |
Antal sider | 5 |
ISSN | 1083-3668 |
DOI | |
Status | Udgivet - maj 2004 |
Bibliografisk note
Funding Information:
The authors gratefully acknowledge the participation of patients and personnel at the Copenhagen University Hospital and thank Foss Electric A/S for access to their thermostatted flow cell for this experiment. They further gratefully acknowledge financial support from the Danish Pharmaceutical Association, the Augustinus Foundation, and the Director Ib Hen-riksen Foundation.
ID: 310770625