Moustapha Saad El-Deen Kassem
Affiliate Professor
Morphogenesis and Differentiation Program
Blegdamsvej 3
2200 København N.
- 2024
- Published
Evidence of steady-state fibroblast subtypes in the normal human breast as cells-of-origin for perturbed-state fibroblasts in breast cancer
Bagger, M. M., Sjölund, J., Kim, Jiyoung, Kohler, Katharina Theresa, Villadsen, René, Jafari Kermani, Abbas, Kassem, Moustapha Saad El-Deen, Pietras, K., Rønnov-Jessen, Lone & Petersen, Ole William, 2024, In: Breast Cancer Research. 26, 1, 19 p., 11.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Cysteine Protease Legumain Is Upregulated by Vitamin D and Is a Regulator of Vitamin D Metabolism in Mice
Forbord, K. M., Okla, M., Lunde, N. N., Bosnjak-Olsen, T., Arnekleiv, G., Hesselson, D., Johansen, H. T., Tang, J. C. Y., Kassem, Moustapha Saad El-Deen, Solberg, R. & Jafari Kermani, Abbas, 2024, In: Cells. 13, 1, 16 p., 36.Research output: Contribution to journal › Journal article › Research › peer-review
- 2023
- Published
Disturbed bone marrow adiposity in patients with Cushing’s syndrome and glucocorticoid- and postmenopausal- induced osteoporosis
Sørensen, N. N., Andreasen, C. M., Jensen, P. R., Hauge, E. M., Bollerslev, J., Delaissé, J. M., Kassem, Moustapha Saad El-Deen, Jafari Kermani, Abbas, Diaz-delCastillo, M. & Andersen, T. L., 2023, In: Frontiers in Endocrinology. 14, 14 p., 1232574.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identifying Biomarkers for Osteogenic Potency Assay Development
Burns, J. S. & Kassem, Moustapha Saad El-Deen, 2023, Potency Assays for Advanced Stem Cell Therapy Medicinal Products. Burns, J. S. (ed.). Springer, p. 39-58 (Advances in Experimental Medicine and Biology, Vol. 1420).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
KIAA1199 deficiency enhances skeletal stem cell differentiation to osteoblasts and promotes bone regeneration
Chen, L., Shi, K., Ditzel, N., Qiu, W., Figeac, F., Nielsen, L. H. D., Tencerova, M., Kowal, J. M., Ding, M., Andreasen, C. M., Andersen, T. L. & Kassem, Moustapha Saad El-Deen, 2023, In: Nature Communications. 14, 1, 2016.Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
High-fat diet-induced obesity augments the deleterious effects of estrogen deficiency on bone: Evidence from ovariectomized mice
Ali, D., Figeac, F., Caci, A., Ditzel, N., Schmal, Clarissa, Kerckhofs, G., Havelund, J., Færgeman, N., Rauch, A., Tencerova, M. & Kassem, Moustapha Saad El-Deen, 2022, In: Aging Cell. 21, 12, e13726.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Impaired Bone Fracture Healing in Type 2 Diabetes Is Caused by Defective Functions of Skeletal Progenitor Cells
Figeac, F., Tencerova, M., Ali, D., Andersen, T. L., Appadoo, D. R. C., Kerckhofs, G., Ditzel, N., Kowal, J. M., Rauch, A. & Kassem, Moustapha Saad El-Deen, 2022, In: Stem Cells. 40, 2, p. 149-164 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Mammalian Cysteine Protease Legumain in Health and Disease
Solberg, R., Lunde, N. N., Forbord, K. M., Okla, M., Kassem, Moustapha Saad El-Deen & Jafari Kermani, Abbas, 2022, In: International Journal of Molecular Sciences. 23, 24, 15983.Research output: Contribution to journal › Review › Research › peer-review
- Published
The pathophysiology of osteoporosis in obesity and type 2 diabetes in aging women and men: The mechanisms and roles of increased bone marrow adiposity
Ali, D., Tencerova, M., Figeac, F., Kassem, Moustapha Saad El-Deen & Jafari Kermani, Abbas, 2022, In: Frontiers in Endocrinology. 13, 981487.Research output: Contribution to journal › Review › Research › peer-review
- Published
ZAKβ is activated by cellular compression and mediates contraction-induced MAP kinase signaling in skeletal muscle
Nordgaard, C., Vind, A. C., Stonadge, A., Kjøbsted, R., Snieckute, G., Antas, P., Blasius, M., Reinert, M. S., Del Val, A. M., Bekker-Jensen, D. B., Haahr, P., Miroshnikova, Y. A., Mazouzi, A., Falk, S., Perrier-Groult, E., Tiedje, C., Li, X., Jakobsen, J. R., Jørgensen, N. O., Wojtaszewski, J. & 12 others, , 2022, In: E M B O Journal. 41, 17, 19 p., e111650.Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
Bone From Blood: Characteristics and Clinical Implications of Circulating Osteogenic Progenitor (COP) Cells
Feehan, J., Kassem, Moustapha Saad El-Deen, Pignolo, R. J. & Duque, G., 2021, In: Journal of Bone and Mineral Research. 36, 1, p. 12-23Research output: Contribution to journal › Review › Research › peer-review
- Published
Bone marrow adipose tissue: Role in bone remodeling and energy metabolism
Tencerova, M., Ferencakova, M. & Kassem, Moustapha Saad El-Deen, 2021, In: Best Practice and Research: Clinical Endocrinology and Metabolism. 35, 4, 15 p., 101545.Research output: Contribution to journal › Review › Research › peer-review
- Published
Identification of a clinical signature predictive of differentiation fate of human bone marrow stromal cells
Kowal, J. M., Möller, S., Ali, D., Figeac, F., Barington, T., Schmal, H. & Kassem, Moustapha Saad El-Deen, 2021, In: Stem Cell Research and Therapy. 12, 15 p., 265.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
JAK2 Inhibition by Fedratinib Reduces Osteoblast Differentiation and Mineralisation of Human Mesenchymal Stem Cells
AlMuraikhi, N., Alaskar, H., Binhamdan, S., Alotaibi, A., Kassem, Moustapha Saad El-Deen & Alfayez, M., 2021, In: Molecules (Basel, Switzerland). 26, 3, 12 p., 606.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular differences of adipose-derived mesenchymal stem cells between non-responders and responders in treatment of transphincteric perianal fistulas
Tencerova, M., Lundby, L., Buntzen, S., Norderval, S., Hougaard, H. T., Pedersen, B. G. & Kassem, Moustapha Saad El-Deen, 2021, In: Stem Cell Research and Therapy. 12, 586.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Myeloma-modified adipocytes exhibit metabolic dysfunction and a senescence-associated secretory phenotype (SASP)
Fairfield, H., Dudakovic, A., Khatib, C. M., Farrell, M., Costa, S., Falank, C., Hinge, M., Murphy, C. S., DeMambro, V., Pettitt, J. A., Lary, C. W., Driscoll, H. E., McDonald, M. M., Kassem, Moustapha Saad El-Deen, Rosen, C., Andersen, T. L., van Wijnen, A. J., Jafari Kermani, Abbas & Reagan, M. R., 2021, In: Cancer Research. 81, 3, p. 634–647Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Relationship between Bone and Reproductive Hormones beyond Estrogens and Androgens
Mills, E. G., Yang, L., Nielsen, M. F., Kassem, Moustapha Saad El-Deen, Dhillo, W. S. & Comninos, A. N., 2021, In: Endocrine Reviews. 42, 6, p. 691-719 29 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
The antiresorptive effect of GIP, but not GLP-2, is preserved in patients with hypoparathyroidism - a randomized crossover study
Skov-Jeppesen, Kirsa, Hepp, N., Oeke, J., Hansen, M. S., Jafari Kermani, Abbas, Svane, M. S., Balenga, N., Olson, J. A., Frost, M., Kassem, Moustapha Saad El-Deen, Madsbad, Sten, Jensen, Jens-Erik Beck, Holst, Jens Juul, Rosenkilde, Mette & Hartmann, Bolette, 2021, In: Journal of Bone and Mineral Research. 36, 8, p. 1448-1458 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Thermogenic potentials of bone marrow adipocytes
Okla, M. & Kassem, Moustapha Saad El-Deen, 2021, In: Bone. 143, 115658.Research output: Contribution to journal › Review › Research › peer-review
- 2020
- Published
ARDD 2020: from aging mechanisms to interventions
Mkrtchyan, G. V., Abdelmohsen, K., Andreux, P., Bagdonaite, I., Barzilai, N., Brunak, S., Cabreiro, F., Cabo, R. D., Campisi, J., Cuervo, A. M., Demaria, M., Ewald, C. Y., Fang, E. F., Faragher, R., Ferrucci, L., Freund, A., Silva-García, C. G., Georgievskaya, A., Gladyshev, V. N., Glass, D. J. & 46 others, , 2020, In: Aging. 12, 24, p. 24486-24503 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Delta-like 1 (DLK1) is a possible mediator of vitamin D effects on bone and energy metabolism
Bassatne, A., Jafari Kermani, Abbas, Kassem, Moustapha Saad El-Deen, Mantzoros, C., Rahme, M. & El-Hajj Fuleihan, G., 2020, In: Bone. 138, 115510.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Fibroblasts direct differentiation of human breast epithelial progenitors
Morsing, M., Kim, Jiyoung, Villadsen, René, Goldhammer, N., Jafari Kermani, Abbas, Kassem, Moustapha Saad El-Deen, Petersen, Ole William & Rønnov-Jessen, Lone, 2020, In: Breast Cancer Research. 22, 16 p., 102.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Generation of Inducible CRISPRi and CRISPRa Human Stromal/Stem Cell Lines for Controlled Target Gene Transcription during Lineage Differentiation
Chen, L., Shi, K., Qiu, W., Aagaard, L. & Kassem, Moustapha Saad El-Deen, 2020, In: Stem Cells International. 2020, 11 p., 8857344.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Less is more: Corroborating a genomic biomarker identifying human bone marrow multipotent stromal cells with high scalability
Burns, J. S. & Kassem, Moustapha Saad El-Deen, 2020, In: Stem Cells. 38, 11, p. E5-E6Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
MicroRNA-3148 acts as molecular switch promoting malignant transformation and adipocytic differentiation of immortalized human bone marrow stromal cells via direct targeting of the SMAD2/TGFβ pathway
Vishnubalaji, R., Elango, R., Manikandan, M., Siyal, A. A., Ali, D., Al-Rikabi, A., Hamam, D., Hamam, R., Benabdelkamel, H., Masood, A., Alanazi, I. O., Alfadda, A. A., Alfayez, M., Aldahmash, A., Kassem, Moustapha Saad El-Deen & Alajez, N. M., 2020, In: Cell Death Discovery. 6, 1, 16 p., 79.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Phosphoproteomic profiling reveals a defined genetic program for osteoblastic lineage commitment of human bone marrow-derived stromal stem cells
Barrio-Hernandez, I., Jafari Kermani, Abbas, Rigbolt, K. T. G., Hallenborg, P., Sanchez-Quiles, V., Skovrind, I., Akimov, V., Kratchmarova, I., Dengjel, J., Kassem, Moustapha Saad El-Deen & Blagoev, B., 2020, In: Genome Research. 30, 1, p. 127-137 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Resveratrol inhibits adipocyte differentiation and cellular senescence of human bone marrow stromal stem cells
Ali, D., Chen, L., Kowal, J. M., Okla, M., Manikandan, M., AlShehri, M., AlMana, Y., AlObaidan, R., AlOtaibi, N., Hamam, R., Alajez, N. M., Aldahmash, A., Kassem, Moustapha Saad El-Deen & Alfayez, M., 2020, In: Bone. 133, 115252.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Single-cell high content imaging parameters predict functional phenotype of cultured human bone marrow stromal stem cells
Kowal, J. M., Schmal, H., Halekoh, U., Hjelmborg, J. B. & Kassem, Moustapha Saad El-Deen, 2020, In: Stem Cells Translational Medicine. 9, 2, p. 189-202Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Tankyrase inhibitor XAV-939 enhances osteoblastogenesis and mineralization of human skeletal (mesenchymal) stem cells
Almasoud, N., Binhamdan, S., Younis, G., Alaskar, H., Alotaibi, A., Manikandan, M., Alfayez, M., Kassem, Moustapha Saad El-Deen & AlMuraikhi, N., 2020, In: Scientific Reports. 10, 1, 16746.Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
AlMuraikhi, N., Ali, D., Vishnubalaji, R., Manikandan, M., Atteya, M., Siyal, A., Alfayez, M., Aldahmash, A., Kassem, Moustapha Saad El-Deen & Alajez, N. M., 29 Aug 2019, In: Stem Cells International. 2019, 12 p., 3041262.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A simple and reliable protocol for long-term culture of murine bone marrow stromal (mesenchymal) stem cells that retained their in vitro and in vivo stemness in long-term culture
Abdallah, B. M., Alzahrani, A. M., Abdel-Moneim, A. M., Ditzel, N. & Kassem, Moustapha Saad El-Deen, 2019, In: Biological Procedures Online. 21, 1, 11 p., 3.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Aging and lineage allocation changes of bone marrow skeletal (stromal) stem cells
Nehlin, J. O., Jafari Kermani, Abbas, Tencerova, M. & Kassem, Moustapha Saad El-Deen, 2019, In: Bone. 123, p. 265-273Research output: Contribution to journal › Journal article › Research › peer-review
- Published
CXCR7 signaling promotes breast cancer survival in response to mesenchymal stromal stem cell-derived factors
Al-toub, M., Almohawes, M., Vishnubalaji, R., Alfayez, M., Aldahmash, A., Kassem, Moustapha Saad El-Deen & Alajez, N. M., 2019, In: Cell Death Discovery. 5, 1, 9 p., 87.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hedgehog Signaling Inhibition by Smoothened Antagonist BMS-833923 Reduces Osteoblast Differentiation and Ectopic Bone Formation of Human Skeletal (Mesenchymal) Stem Cells
Almuraikhi, N., Almasoud, N., Binhamdan, S., Younis, G., Ali, D., Manikandan, M., Vishnubalaji, R., Atteya, M., Siyal, A., Alfayez, M., Aldahmash, A., Kassem, Moustapha Saad El-Deen & Alajez, N. M., 2019, In: Stem Cells International. 2019, 12 p., 3435901.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Insulin Signaling in Bone Marrow Adipocytes
Tencerova, M., Okla, M. & Kassem, Moustapha Saad El-Deen, 2019, In: Current Osteoporosis Reports. 17, 6, p. 446-454 9 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
KIAA1199 is a secreted molecule that enhances osteoblastic stem cell migration and recruitment
Chen, L., Shi, K., Andersen, T. L., Qiu, W. & Kassem, Moustapha Saad El-Deen, 2019, In: Cell Death & Disease. 10, 2, p. 126Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lansoprazole inhibits the cysteine protease legumain by binding to the active site
Bosnjak, T., Solberg, R., Hemati, P. D., Jafari Kermani, Abbas, Kassem, Moustapha Saad El-Deen & Johansen, H. T., 2019, In: Basic & Clinical Pharmacology & Toxicology. 125, 2, p. 89-99 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Mesenchymal stem cells isolated from both distal femurs of patients with unilateral trauma or osteoarthritis of the knee exhibit similar in-vitro ability of bone formation
Falster, C., Poulsen, S. S., Storaas, A. M., Schrøder, H. M., Vinther, J. H., Kassem, Moustapha Saad El-Deen & Jørgensen, U., 2019, In: Journal of Orthopaedic Science. 24, 5, p. 918-924Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Metabolic programming determines the lineage-differentiation fate of murine bone marrow stromal progenitor cells
Tencerova, M., Rendina-Ruedy, E., Neess, D., Færgeman, N., Figeac, F., Ali, D., Danielsen, M., Haakonsson, A., Rosen, C. J. & Kassem, Moustapha Saad El-Deen, 2019, In: Bone Research. 7, 1, 14 p., 35.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neoplastic Transformation of Human Mesenchymal Stromal Cells Mediated via LIN28B
Vishnubalaji, R., Elango, R., Al-Toub, M., Manikandan, M., Al-Rikabi, A., Harkness, L., Ditzel, N., Atteya, M., Hamam, R., Alfayez, M., Aldahmash, A., Kassem, Moustapha Saad El-Deen & Alajez, N. M., 2019, In: Scientific Reports. 9, 1, 14 p., 8101.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Obesity-Associated Hypermetabolism and Accelerated Senescence of Bone Marrow Stromal Stem Cells Suggest a Potential Mechanism for Bone Fragility
Tencerova, M., Frost, M., Figeac, F., Nielsen, T. K., Ali, D., Lauterlein, J. J. L., Andersen, T. L., Haakonsson, A. K., Rauch, A., Madsen, J. S., Ejersted, C., Højlund, K. & Kassem, Moustapha Saad El-Deen, 2019, In: Cell Reports. 27, 7, p. 2050-2062.e6Research output: Contribution to journal › Journal article › Research › peer-review
- Published
TAFA2 Induces Skeletal (Stromal) Stem Cell Migration Through Activation of Rac1-p38 Signaling
Jafari Kermani, Abbas, Isa, A., Chen, L., Ditzel, N., Zaher, W., Harkness, L., Johnsen, H. E., Abdallah, B. M., Clausen, C. & Kassem, Moustapha Saad El-Deen, 2019, In: Stem Cells. 37, 3, p. 407-416Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Transit amplifying cells coordinate mouse incisor mesenchymal stem cell activation
Walker, J. V., Zhuang, H., Singer, D., Illsley, C. S., Kok, W. L., Sivaraj, K. K., Gao, Y., Bolton, C., Liu, Y., Zhao, M., Grayson, P. R. C., Wang, S., Karbanová, J., Lee, T., Ardu, S., Lai, Q., Liu, J., Kassem, M., Chen, S., Yang, K. & 7 others, , 2019, In: Nature Communications. 10, 1, 18 p., 3596.Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
- Published
Actin depolymerization enhances adipogenic differentiation in human stromal stem cells
Chen, L., Hu, H., Qiu, W., Shi, K. & Kassem, Moustapha Saad El-Deen, May 2018, In: Stem Cell Research. 29, p. 76-83 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Romidepsin Promotes Osteogenic and Adipocytic Differentiation of Human Mesenchymal Stem Cells through Inhibition of Histondeacetylase Activity
Ali, D., Chalisserry, E. P., Manikandan, M., Hamam, R., Alfayez, M., Kassem, Moustapha Saad El-Deen, Aldahmash, A. & Alajez, N. M., 14 Mar 2018, In: Stem Cells International. 2018, 12 p., 2379546.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Global MicroRNA Profiling in Human Bone Marrow Skeletal-Stromal or Mesenchymal-Stem Cells Identified Candidates for Bone Regeneration
Chang, C., Venø, M. T., Chen, L., Ditzel, N., Le, D. Q. S., Dillschneider, P., Kassem, Moustapha Saad El-Deen & Kjems, J., 7 Feb 2018, In: Molecular therapy : the journal of the American Society of Gene Therapy. 26, 2, p. 593-605 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Antibody-based inhibition of circulating DLK1 protects from estrogen deficiency-induced bone loss in mice
Figeac, F., Andersen, D. C., Nipper Nielsen, C. A., Ditzel, N., Sheikh, S. P., Skjødt, K., Kassem, Moustapha Saad El-Deen, Jensen, C. H. & Abdallah, B. M., 2018, In: Bone. 110, p. 312-320 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
High-Fat Diet–Induced Obesity Promotes Expansion of Bone Marrow Adipose Tissue and Impairs Skeletal Stem Cell Functions in Mice
Tencerova, M., Figeac, F., Ditzel, N., Taipaleenmäki, H., Nielsen, T. K. & Kassem, Moustapha Saad El-Deen, 2018, In: Journal of Bone and Mineral Research. 33, 6, p. 1154-1165 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Induction of quiescence (G0) in bone marrow stromal stem cells enhances their stem cell characteristics
Rumman, M., Majumder, A., Harkness, L., Venugopal, B., Vinay, M. B., Pillai, M. S., Kassem, Moustapha Saad El-Deen & Dhawan, J., 2018, In: Stem Cell Research. 30, p. 69-80 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular profiling of ALDH1+ colorectal cancer stem cells reveals preferential activation of MAPK, FAK, and oxidative stress prosurvival signalling pathways
Vishnubalaji, R., Manikandan, M., Fahad, M., Hamam, R., Alfayez, M., Kassem, Moustapha Saad El-Deen, Aldahmash, A. & Alajez, N. M., 2018, In: OncoTarget. 9, 17, p. 13551-13564 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 41048621
Most downloads
-
242
downloads
Evidence of two distinct functionally specialized fibroblast lineages in breast stroma
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
224
downloads
High-Fat Diet–Induced Obesity Promotes Expansion of Bone Marrow Adipose Tissue and Impairs Skeletal Stem Cell Functions in Mice
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
190
downloads
Actin depolymerization enhances adipogenic differentiation in human stromal stem cells
Research output: Contribution to journal › Journal article › Research › peer-review
Published