Inhibition of GSK3B bypass drug resistance of p53-null colon carcinomas by enabling necroptosis in response to chemotherapy

Research output: Contribution to journalJournal articleResearchpeer-review

  • Emanuela Grassilli
  • Robert Narloch
  • Elena Federzoni
  • Leonarda Ianzano
  • Fabio Pisano
  • Roberto Giovannoni
  • Gabriele Romano
  • Laura Masiero
  • Biagio Eugenio Leone
  • Serena Bonin
  • Marisa Donada
  • Giorgio Stanta
  • Kristian Helin
  • Marialuisa Lavitrano
Evasion from chemotherapy-induced apoptosis due to p53 loss strongly contributes to drug resistance. Identification of specific targets for the treatment of drug-resistant p53-null tumors would therefore increase the effectiveness of cancer therapy.
Original languageEnglish
JournalClinical Cancer Research
Volume19
Issue number14
Pages (from-to)3820-31
Number of pages12
ISSN1078-0432
DOIs
Publication statusPublished - 15 Jul 2013

ID: 94395223