Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits

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  • Joshua C Randall
  • Thomas W Winkler
  • Zoltán Kutalik
  • Sonja I Berndt
  • Anne U Jackson
  • Keri L Monda
  • Oskari Kilpeläinen, Tuomas
  • Tõnu Esko
  • Reedik Mägi
  • Shengxu Li
  • Tsegaselassie Workalemahu
  • Mary F Feitosa
  • Damien C Croteau-Chonka
  • Felix R Day
  • Tove Fall
  • Teresa Ferreira
  • Stefan Gustafsson
  • Adam E Locke
  • Iain Mathieson
  • Andre Scherag
  • Sailaja Vedantam
  • Andrew R Wood
  • Liming Liang
  • Valgerdur Steinthorsdottir
  • Gudmar Thorleifsson
  • Emmanouil T Dermitzakis
  • Antigone S Dimas
  • Fredrik Karpe
  • Josine L Min
  • George Nicholson
  • Deborah J Clegg
  • Thomas Person
  • Jon P Krohn
  • Sabrina Bauer
  • Christa Buechler
  • Kristina Eisinger
  • Amélie Bonnefond
  • Philippe Froguel
  • Jouke-Jan Hottenga
  • Inga Prokopenko
  • Lindsay L Waite
  • Tamara B Harris
  • Albert Vernon Smith
  • Alan R Shuldiner
  • Wendy L McArdle
  • Mark J Caulfield
  • Peter Kovacs
  • Schwarz, Peter
  • Lars Lind
  • Inger Njølstad
  • DIAGRAM Consortium
Given the anthropometric differences between men and women and previous evidence of sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic associations with height, weight, body mass index, waist circumference, hip circumference, and waist-to-hip-ratio (133,723 individuals) and took forward 348 SNPs into follow-up (additional 137,052 individuals) in a total of 94 studies. Seven loci displayed significant sex-difference (FDR
Original languageEnglish
Article numbere1003500
JournalP L o S Genetics
Volume9
Issue number6
Pages (from-to)1-19
Number of pages20
ISSN1553-7390
DOIs
Publication statusPublished - Jun 2013

ID: 46279463