mapDamage2.0: fast approximate Bayesian estimates of ancient DNA damage parameters
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- Jonsson_2013_mapDamage
Final published version, 137 KB, PDF document
Ancient DNA (aDNA) molecules in fossilized bones and teeth, coprolites, sediments, mummified specimens and museum collections represent fantastic sources of information for evolutionary biologists, revealing the agents of past epidemics and the dynamics of past populations. However, the analysis of aDNA generally faces two major issues. Firstly, sequences consist of a mixture of endogenous and various exogenous backgrounds, mostly microbial. Secondly, high nucleotide misincorporation rates can be observed as a result of severe post-mortem DNA damage. Such misincorporation patterns are instrumental to authenticate ancient sequences versus modern contaminants. We recently developed the user-friendly mapDamage package that identifies such patterns from next-generation sequencing (NGS) sequence datasets. The absence of formal statistical modeling of the DNA damage process, however, precluded rigorous quantitative comparisons across samples.
Original language | English |
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Journal | Bioinformatics |
Volume | 29 |
Issue number | 13 |
Pages (from-to) | 1682-1684 |
Number of pages | 3 |
ISSN | 1367-4803 |
DOIs | |
Publication status | Published - 1 Jul 2013 |
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