Insulin infusion reduces hepatocyte growth factor in lean humans
Research output: Contribution to journal › Journal article › Research › peer-review
OBJECTIVE: Plasma Hepatocyte Growth Factor (HGF) is significantly elevated in obesity and may contribute to vascular disease, metabolic syndrome or cancer in obese individuals. The current studies were done to determine if hyperinsulinemia increases plasma HGF. MATERIALS/METHODS: Twenty-two participants (10 women/12 men, BMI 20.6-34.5 kg/m(2), age 18-49 years) underwent a hyperinsulinemic euglycemic clamp with measurement of HGF at baseline and steady state. Relationships between baseline HGF, anthropometrics, triglycerides, liver enzymes, c-reactive protein and adiponectin were also evaluated. RESULTS: Fasting HGF was positively correlated (P
Original language | English |
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Journal | Metabolism |
Volume | 62 |
Issue number | 5 |
Pages (from-to) | 647-650 |
Number of pages | 4 |
ISSN | 0026-0495 |
DOIs | |
Publication status | Published - May 2013 |
ID: 43232861