Clinical outcome in 520 consecutive Danish rectal cancer patients treated with short course preoperative radiotherapy
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AIM: The purpose of this study was to analyse the results of preoperative short course radiotherapy in a consecutive, national cohort of patients with rectal cancer. METHODS: Through a validated, prospective national database we identified 520 Danish patients who presented with high-risk mobile tumours in the lower two thirds of the rectum and were referred for preoperative radiotherapy with 5 x 5 Gy. The inclusion period was 56 months. Radiotherapy data was retrospectively collected. RESULTS: Of the 520 patients, 514 completed radiotherapy and 506 had surgery. Surgery was considered curative in 439 patients. The 3-year local recurrence rate was 4.0% (95% CI 2.5-6.5%) and the distant recurrence rate at 3 years was 18.7% (95% CI 15.4-22.5%). The 5-year disease free survival rate was 40.2% (95% CI 27.0-53.1%) and overall survival 50.4% (95% CI 36.1-63.1%). Most tumours (61%) were classified as T3 or T4 and 41% of the local recurrences occurred in patients with a fixed tumour at surgery. CONCLUSION: This study confirms data from randomised studies that the short course 5 x 5 Gy regime is a feasible treatment for locally advanced rectal cancer even when applied in a population outside clinical trials.
Original language | English |
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Journal | European Journal of Surgical Oncology |
Volume | 36 |
Issue number | 3 |
Pages (from-to) | 237-43 |
Number of pages | 6 |
ISSN | 0748-7983 |
DOIs | |
Publication status | Published - 2010 |
Bibliographical note
Keywords: Adult; Aged; Aged, 80 and over; Colectomy; Denmark; Female; Follow-Up Studies; Humans; Incidence; Male; Middle Aged; Neoplasm Recurrence, Local; Preoperative Care; Prospective Studies; Rectal Neoplasms; Survival Rate; Time Factors; Treatment Outcome
ID: 19441566