Platelet count kinetics following interruption of antiretroviral treatment
Research output: Contribution to journal › Journal article › Research › peer-review
To investigate the mechanisms of platelet kinetics in the Strategies for Management of Antiretroviral Therapy (SMART) study that demonstrated excess mortality with CD4 guided episodic antiretroviral therapy (ART) drug conservation compared with continuous treatment viral suppression. Follow-up analyses of stored plasma samples demonstrated increased activation of both inflammatory and coagulation pathways after stopping ART.
| Original language | English |
|---|---|
| Journal | AIDS (London, England) |
| Volume | 27 |
| Issue number | 1 |
| Pages (from-to) | 59-68 |
| Number of pages | 10 |
| DOIs | |
| Publication status | Published - 2 Jan 2013 |
- Adult, Anti-HIV Agents, Antifibrinolytic Agents, Biological Markers, Blood Coagulation, CD4 Lymphocyte Count, Drug Administration Schedule, Female, Fibrin Fibrinogen Degradation Products, Follow-Up Studies, HIV Seropositivity, Humans, Inflammation, Male, Middle Aged, Platelet Count, Proportional Hazards Models, Retrospective Studies, Treatment Outcome, Viral Load, Virus Replication
Research areas
ID: 93928648