Complement activation by PEG-functionalized multi-walled carbon nanotubes is independent of PEG molecular mass and surface density
Research output: Contribution to journal › Journal article › Research › peer-review
Carboxylated (4%) multi-walled carbon nanotubes were covalently functionalized with poly(ethylene glycol)1000 (PEG1000), PEG1500 and PEG4000 with a PEG loading of approximately 11% in all cases. PEG loading generated non-uniform and heterogeneous higher surface structures and increased nanotube width considerably, but all PEGylated nanotube species activated the complement system in human serum equally. Increased PEG loading, through adsorption of methoxyPEG2000(or 5000)-phospholipid conjugates, generated fewer complement activation products; however, complement activation was never completely eliminated. Our observations address the difficulty in making carbon nanotubes more compatible with innate immunity through covalent PEG functionalization as well as double PEGylation strategies.
Original language | English |
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Journal | Nanomedicine: Nanotechnology, Biology and Medicine |
Volume | 9 |
Issue number | 4 |
Pages (from-to) | 469-473 |
Number of pages | 5 |
ISSN | 1549-9634 |
DOIs | |
Publication status | Published - 1 May 2013 |
- Atomic force microscope, Carbon nanotubes, Complement system, Innate immunity, Poly(ethylene glycol)
Research areas
ID: 120513468