MSH6 mutations are frequent in hereditary nonpolyposis colorectal cancer families with normal pMSH6 expression as detected by immunohistochemistry
Research output: Contribution to journal › Journal article › Research › peer-review
Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant condition accounting for 2% to 4% of all colorectal cancer cases worldwide. Families with germ line mutations in 1 of 6 mismatch repair genes are known as Lynch syndrome families. The largest number of mutations has been detected in the mismatch repair genes MLH1 and MSH2, but several mutations in MSH6 have also been demonstrated.
| Original language | English |
|---|---|
| Journal | Applied Immunohistochemistry & Molecular Morphology |
| Volume | 20 |
| Issue number | 5 |
| Pages (from-to) | 470-477 |
| Number of pages | 8 |
| ISSN | 1541-2016 |
| DOIs | |
| Publication status | Published - 2012 |
ID: 48426112