Immune responses to hair dyes containing toluene-2,5-diamine
Research output: Contribution to journal › Journal article › Research › peer-review
BACKGROUND: Toluene-2,5-diamine (PTD) is the most frequently used dye in oxidative hair dyes on the Scandinavian market. However, little is known about immune responses to PTD-containing oxidative hair dyes.
OBJECTIVES: To study immune responses induced by PTD-containing hair dyes in mice.
METHODS: Immune responses against two different permanent hair dye products containing 1·60% (w/w) and 0·48% (w/w) PTD within the colour gel, and various concentrations of pure PTD were studied. The local inflammatory response was measured by ear swelling and cell infiltration, and T- and B-cell infiltration and proliferation was determined in the draining lymph nodes.
RESULTS: Concentration-dependent immune responses were seen to PTD both in the skin and draining lymph nodes. The hair dye containing 1·60% PTD induced strong local inflammation and caused T- and B-cell infiltration and proliferation as well as an increased number of regulatory T cells in the draining lymph nodes. In contrast, the hair dye containing 0·48% PTD induced skin inflammation but only minor responses in the draining lymph nodes.
CONCLUSIONS: Consumer-available PTD-containing permanent hair dyes can be potent immune activators inducing both pro- and anti-inflammatory responses. The outcome of the response is dependent on allergen dose, amount of additional allergens and exposure regime.
Original language | English |
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Journal | British Journal of Dermatology |
Volume | 170 |
Issue number | 2 |
Pages (from-to) | 352-9 |
Number of pages | 8 |
ISSN | 0007-0963 |
DOIs | |
Publication status | Published - Feb 2014 |
- Animals, B-Lymphocytes, Female, Hair Dyes, Immunity, Cellular, Inflammation, Mice, Inbred C57BL, Phenylenediamines, T-Lymphocytes, Regulatory
Research areas
ID: 135491255