Effect of local hemostatics on bone induction in rats: a comparative study of bone wax, fibrin-collagen paste, and bioerodible polyorthoester with and without gentamicin
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Local hemostatics for osseous tissue should preferably be absorbable and biocompatible and should not inhibit osteogenesis. The tissue response and effect on demineralized bone-induced heterotopic osteogenesis in the abdominal muscle of 120 male Wistar rats by different local hemostatics were evaluated by light microscopy and 85Sr uptake analyses. Non-absorbable bone wax of 88% beeswax and absorbable bovine fibrin-collagen paste both significantly inhibited osteoinduction, whereas a bioerodible polyorthoester drug delivery system with or without 4% gentamicin did not. Bone wax was not absorbed and induced a chronic foreign body reaction. Fibrin-collagen paste induced less inflammation with numerous monocytes and macrophages with engulfed material. Bioerodible polyorthoester caused a very moderate tissue reaction and was mostly resorbed at week 4.
Original language | English |
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Journal | Journal of Biomedical Materials Research |
Volume | 26 |
Issue number | 6 |
Pages (from-to) | 791-800 |
Number of pages | 10 |
ISSN | 0021-9304 |
DOIs | |
Publication status | Published - 1 Jun 1992 |
- Absorption, Animals, Biocompatible Materials, Bone and Bones, Collagen, Drug Combinations, Fibrin, Gentamicins, Hemostatics, Inflammation, Male, Materials Testing, Osteogenesis, Palmitates, Polyesters, Rats, Rats, Inbred Strains, Waxes
Research areas
ID: 33984782