High glucose impairs superoxide production from isolated blood neutrophils
Research output: Contribution to journal › Journal article › Research › peer-review
Superoxide (O(2)(-)), a key antimicrobial agent in phagocytes, is produced by the activity of NADPH oxidase. High glucose concentrations may, however, impair the production of O(2)(-) through inhibition of glucose-6-phosphate dehydrogenase (G6PD), which catalyzes the formation of NADPH. This study measured the acute effects of high glucose or the G6PD inhibitor dehydroepiandrosterone (DHEA) on the production of O(2)(-) from isolated human neutrophils.
Original language | English |
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Journal | Intensive Care Medicine |
Volume | 29 |
Issue number | 4 |
Pages (from-to) | 642-5 |
Number of pages | 4 |
ISSN | 0342-4642 |
DOIs | |
Publication status | Published - Apr 2003 |
ID: 48553034