Recovery From SIADH-Associated Osteoporosis: A Case Report
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INTRODUCTION: Recent studies show an association between hyponatremia and osteoporosis. We have previously reported a case of severe male osteoporosis due to chronic syndrome of inappropriate secretion of antidiuretic hormone (SIADH). Here, we provide a follow-up on this case after cure of the condition that further supports the causal relationship.
THE CASE: A 38-year-old man had been diagnosed with severe osteoporosis most likely due to chronic SIADH. The SIADH was believed to be idiopathic. A magnetic resonance imaging scan, however, revealed a tumor in the sinus, and biopsies showed an esthesioneuroblastoma, immunohistochemically positive for antidiuretic hormone (ADH). After the tumor was removed, ADH and sodium levels normalized. A dual-energy x-ray absorptiometry scan performed 7 months after the patient's last surgery showed a significant spontaneous improvement in bone mineral density in the lumbar vertebrae.
CONCLUSION: This case provides evidence for a causal relationship between SIADH and chronic hyponatremia and impaired bone metabolism that can lead to severe secondary osteoporosis. The effect on bone metabolism is at least partially reversible.
Original language | English |
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Journal | Journal of Clinical Endocrinology and Metabolism |
Volume | 99 |
Issue number | 10 |
Pages (from-to) | 3527-3530 |
Number of pages | 4 |
ISSN | 0021-972X |
DOIs | |
Publication status | Published - 2014 |
- Adult, Esthesioneuroblastoma, Olfactory, Humans, Hyponatremia, Inappropriate ADH Syndrome, Male, Multimodal Imaging, Nasal Cavity, Nose Neoplasms, Osteoporosis
Research areas
ID: 138146035