Studies of the Ala/Val98 polymorphism of the hepatocyte nuclear factor-1alpha gene and the relationship to beta-cell function during an OGTT in glucose-tolerant women with and without previous gestational diabetes mellitus

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In pregnancies complicated by gestational diabetes mellitus (GDM) an increased demand for insulin is not met due to beta-cell dysfunction. An Ala/Val polymorphism at codon 98 of the hepatocyte nuclear factor-1alpha (HNF-1alpha) gene has been associated with decreased serum insulin and C-peptide responses during an oral glucose tolerance test (OGTT) in glucose-tolerant subjects. The aims of the present study were to evaluate the influence of the polymorphism on the serum insulin and C-peptide responses to an OGTT in glucose-tolerant women with and without previous GDM and to investigate if this polymorphism is associated with GDM.
Original languageEnglish
JournalDiabetic Medicine
Volume21
Issue number12
Pages (from-to)1310-5
Number of pages6
ISSN0742-3071
DOIs
Publication statusPublished - Dec 2004

    Research areas

  • Adult, C-Peptide, Case-Control Studies, DNA-Binding Proteins, Diabetes, Gestational, Female, Glucose Tolerance Test, Hepatocyte Nuclear Factor 1, Hepatocyte Nuclear Factor 1-alpha, Humans, Insulin, Islets of Langerhans, Nuclear Proteins, Polymorphism, Genetic, Pregnancy, Statistics, Nonparametric, Transcription Factors

ID: 92192045