Combinations of genetic data in a study of neuroblastoma risk genotypes
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Analysis of combinations of genetic changes that occur exclusively in patients may be a supplementary strategy to the single-locus strategy used in many genetic studies. The genotypes of 16 SNPs within susceptibility loci for neuroblastoma (NB) were analyzed in a previous study. In the present study, combinations of these genotypes have been analyzed. The theoretical number of combinations of 3 SNP genotypes taken from 16 SNPs is 15,120. Of these, 14,307 were found in 370 patients and 803 controls; 12,772 combinations were common to both patients and controls; 1,213 were found in controls only; and 322 combinations were found in patients only. Among the latter, a cluster of 24 combinations was found to be significantly associated with NB (P < 0.00001).
Original language | English |
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Journal | Cancer genetics and cytogenetics |
Volume | 207 |
Issue number | 3 |
Pages (from-to) | 94-7 |
Number of pages | 4 |
ISSN | 0165-4608 |
DOIs | |
Publication status | Published - Mar 2014 |
- Genotype, Humans, Neuroblastoma, Polymorphism, Single Nucleotide
Research areas
ID: 138817658