Studies of association of AGPAT6 variants with type 2 diabetes and related metabolic phenotypes in 12,068 Danes
Research output: Contribution to journal › Journal article › Research › peer-review
Type 2 diabetes, obesity and insulin resistance are characterized by hypertriglyceridemia and ectopic accumulation of lipids in liver and skeletal muscle. AGPAT6 encodes a novel glycerol-3 phosphate acyltransferase, GPAT4, which catalyzes the first step in the de novo triglyceride synthesis. AGPAT6-deficient mice show lower weight and resistance to diet- and genetically induced obesity. Here, we examined whether common or low-frequency variants in AGPAT6 associate with type 2 diabetes or related metabolic traits in a Danish population.
Original language | English |
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Journal | BMC Medical Genetics |
Volume | 14 |
Issue number | 1 |
Pages (from-to) | 113 |
ISSN | 1471-2350 |
DOIs | |
Publication status | Published - 25 Oct 2013 |
ID: 66819335