Metformin protects against lipoapoptosis and enhances GLP-1 secretion from GLP-1-producing cells
Research output: Contribution to journal › Journal article › Research › peer-review
Metformin is the most frequently prescribed drug for treatment of type 2 diabetes. It improves insulin resistance and glycemia by reducing hepatic gluconeogenesis. In addition, diabetic patients on metformin therapy have elevated levels of the insulinotropic hormone glucagon-like peptide-1 (GLP-1) and metformin has been shown to regulate the expression of the GLP-1R in the pancreas.
Original language | English |
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Journal | Journal of Gastroenterology |
Volume | 48 |
Issue number | 3 |
Pages (from-to) | 322-32 |
Number of pages | 11 |
ISSN | 0944-1174 |
DOIs | |
Publication status | Published - Mar 2013 |
ID: 45840439