Azide- and Alkyne-Functionalised α- and β3-Amino Acids
Research output: Contribution to journal › Journal article › Research › peer-review
The synthesis and full characterisation of bifunctional β -amino acids that have side chains functionalised with terminal azides (S)-4 and (R)-4 or acetylenes 5 and 6 is reported for the first time. The building blocks incorporate a turn-inducing β -segment and a side chain that can be functionalised further, for example, through copper-catalysed Huisgen cycloaddition. Moreover, the corresponding α-amino acids 1 and 3 have been synthesised and characterised. All amino acid building blocks were of high optical purity as demonstrated by derivatisation and subsequent NMR analysis.
Original language | English |
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Journal | SYNLETT: Accounts and Rapid Communications in Chemical Synthesis |
Volume | 23 |
Issue number | 18 |
Pages (from-to) | 2643-2646 |
Number of pages | 4 |
ISSN | 0936-5214 |
DOIs | |
Publication status | Published - 1 Jan 2012 |
ID: 49635928