Nucleocytoplasmic shuttling of transcription factors.
Research output: Contribution to journal › Review › Research › peer-review
To elicit the transcriptional response following intra- or extracellular stimuli, the signals need to be transmitted to their site of action within the nucleus. The nucleocytoplasmic shuttling of transcription factors is a mechanism mediating this process. The activation and inactivation of the transcriptional response is essential for cells to progress through the cell cycle in a normal manner. The involvement of cytoplasmic and nuclear accessory molecules, and the general nuclear membrane transport components, are essential for this process. Although nuclear import and export for different transcription factor families are regulated by similar mechanisms, there are several differences that allow for the specific activation of each transcription factor. This review discusses the general import and export pathways found to be common amongst many different transcription factors, and highlights a select group of transcription factors that demonstrate the diversity displayed in their mode of activation and inactivation.
Original language | English |
---|---|
Journal | Cellular and Molecular Life Sciences |
Volume | 57 |
Issue number | 8-9 |
Pages (from-to) | 1193-206 |
Number of pages | 13 |
ISSN | 1420-682X |
Publication status | Published - 2000 |
Bibliographical note
Keywords: Animals; Cell Cycle; Cell Nucleus; Cytoplasm; Gene Expression Regulation; Humans; Protein Transport; Transcription Factors; Transcription, Genetic
ID: 5052826