The effects of continuous prostacyclin infusion on regional blood flow and cerebral vasospasm following subarachnoid haemorrhage: study protocol for a randomised controlled trial
Research output: Contribution to journal › Journal article › Research › peer-review
One of the main causes of mortality and morbidity following subarachnoid haemorrhage (SAH) is the development of cerebral vasospasm, a frequent complication arising in the weeks after the initial bleeding. Despite extensive research, to date no effective treatment of vasospasm exists. Prostacyclin is a potent vasodilator and inhibitor of platelet aggregation. In vitro models have shown a relaxing effect of prostacyclin after induced contraction in cerebral arteries, and a recent pilot trial showed a positive effect on cerebral vasospasm in a clinical setting. No randomised, clinical trials have been conducted, investigating the possible pharmacodynamic effects of prostacyclin on the human brain following SAH.
Original language | English |
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Article number | 102 |
Journal | Trials |
Volume | 13 |
Pages (from-to) | 1-6 |
Number of pages | 6 |
ISSN | 1745-6215 |
DOIs | |
Publication status | Published - 2012 |
- Cerebral Angiography, Cerebral Arteries, Cerebrovascular Circulation, Denmark, Epoprostenol, Glasgow Coma Scale, Humans, Infusions, Parenteral, Microdialysis, Perfusion Imaging, Pilot Projects, Regional Blood Flow, Research Design, Subarachnoid Hemorrhage, Time Factors, Tomography, X-Ray Computed, Treatment Outcome, Vasoconstriction, Vasodilator Agents, Vasospasm, Intracranial
Research areas
ID: 47239496