Endothelial cell death and intimal foam cell accumulation in the coronary artery of infected hypercholesterolemic minipigs
Research output: Contribution to journal › Journal article › Research › peer-review
Apoptosis of endothelial cells (ECs) has been suggested to play a role in atherosclerosis. We studied the synergism of hypercholesterolemia with Chlamydia pneumoniae and influenza virus infections on EC morphology and intimal changes in a minipig model. The coronary artery was excised at euthanasia (19 weeks of age) and serial sections were processed for the detection of EC apoptosis, histology, and transmission electron microscopy (TEM) studies. There was a significantly higher number of TUNEL-positive ECs in infected compared to noninfected groups [0.2942 % (interquartile ranges (IR), 0.2941; n¿=¿26) versus 0 % (IR, 0; n¿=¿12), p¿
| Original language | English |
|---|---|
| Journal | Journal of Cardiovascular Translational Research |
| Volume | 6 |
| Issue number | 4 |
| Pages (from-to) | 579-587 |
| Number of pages | 9 |
| ISSN | 1937-5387 |
| DOIs | |
| Publication status | Published - 2013 |
ID: 45708526