Peripheral blood cell signatures of Plasmodium falciparum infection during pregnancy

Research output: Contribution to journalJournal articleResearchpeer-review

  • Samad Ibitokou
  • Mayke Oesterholt
  • Laurent Brutus
  • Sophie Borgella
  • Carine Agbowaï
  • Sèm Ezinmègnon
  • John Lusingu
  • Schmiegelow, Christentze
  • Achille Massougbodji
  • Philippe Deloron
  • Marita Troye-Blomberg
  • Stefania Varani
  • Adrian J F Luty
  • Nadine Fievet
Sequestration of Plasmodium falciparum-infected erythrocytes in placental intervillous spaces causes inflammation and pathology. Knowledge of the profiles of immune cells associated with the physiopathology of pregnancy-associated malaria (PAM) is scarce. We conducted a longitudinal, prospective study, both in Benin and Tanzania, including ~1000 pregnant women in each site with systematic follow-up at scheduled antenatal visits until delivery. We used ex vivo flow cytometry to identify peripheral blood mononuclear cell (PBMC) profiles that are associated with PAM and anaemia, determining the phenotypic composition and activation status of PBMC in selected sub-groups with and without PAM both at inclusion and at delivery in a total of 302 women. Both at inclusion and at delivery PAM was associated with significantly increased frequencies both of B cells overall and of activated B cells. Infection-related profiles were otherwise quite distinct at the two different time-points. At inclusion, PAM was associated with anaemia, with an increased frequency of immature monocytes and with a decreased frequency of regulatory T cells (Treg). At delivery, infected women presented with significantly fewer plasmacytoid dendritic cells (DC), more myeloid DC expressing low levels of HLA-DR, and more effector T cells (Teff) compared to uninfected women. Independent associations with an increased risk of anaemia were found for altered antigen-presenting cell frequencies at inclusion, but for an increased frequency of Teff at delivery. Our findings emphasize the prominent role played by B cells during PAM whenever it arises during pregnancy, whilst also revealing signature changes in other circulating cell types that, we conclude, primarily reflect the relative duration of the infections. Thus, the acute, recently-acquired infections present at delivery were marked by changes in DC and Teff frequencies, contrasting with infections at inclusion, considered chronic in nature, that were characterized by an abundance of immature monocytes and a paucity of Treg in PBMC.
Original languageEnglish
JournalP L o S One
Volume7
Issue number12
Pages (from-to)e49621
ISSN1932-6203
DOIs
Publication statusPublished - 2012

ID: 43233759