Low ABCB1 gene expression is an early event in colorectal carcinogenesis
Research output: Contribution to journal › Journal article › Research › peer-review
The ABCB1/MDR1 gene product ABCB1/P-glycoprotein is implicated in the development of colorectal cancer (CRC). NFKB1 encodes transcription factors regulating expression of a number of genes including ABCB1. We have previously found association between the ABCB1 C-rs3789243-T polymorphism and CRC risk and interactions between the ABCB1 C-rs3789243-T and C3435T polymorphisms and meat intake in relation to CRC risk (Andersen, BMC Cancer, 2009, 9, 407). ABCB1 and NFKB1 mRNA levels were assessed in intestinal tissue from 122 CRC cases, 101 adenoma cases (12 with severe dysplasia, 89 with mild-moderate dysplasia) and from 18 healthy individuals, together with gene polymorphisms in ABCB1 and NFKB1. ABCB1 mRNA levels were highest in the healthy individuals and significantly lower in mild/moderate and severe dysplasia tissue (P
| Original language | English |
|---|---|
| Journal | PloS one |
| Volume | 8 |
| Issue number | 8 |
| Pages (from-to) | e72119 |
| ISSN | 1932-6203 |
| DOIs | |
| Publication status | Published - Aug 2013 |
- Adenoma, Carcinogenesis, Carcinoma, Case-Control Studies, Colon, Colorectal Neoplasms, Female, Gene Expression, Humans, INDEL Mutation, Male, Middle Aged, NF-kappa B p50 Subunit, P-Glycoprotein, Polymorphism, Single Nucleotide, RNA, Messenger
Research areas
ID: 108665098