A pilot study of muscle plasma protein changes after exercise
Research output: Contribution to journal › Journal article › Research › peer-review
INTRODUCTION: Creatine kinase (CK) and myoglobin (Mb) do not possess all good qualities as biomarkers of skeletal muscle damage. We investigated the utility of troponin I (TnI) and telethonin (Tcap) as markers and examined their temporal profiles after skeletal muscle damage.
METHODS: Plasma profiles were measured before and after exercise in 3 groups: subjects affected by either Becker muscular dystrophy or McArdle disease, and healthy subjects.
RESULTS: Mb and TnI appeared early in the blood, and the increase of TnI was only observed in patients with muscle disease. The CK increase was more delayed in plasma. Tcap was not detectable at any time.
CONCLUSIONS: Our results suggest that TnI is a marker of more severe damage signifying sarcomeric damage, and it could therefore be an important supplement to CK and Mb in clinical practice. Tcap is not useful as a marker for skeletal muscle damage.
| Original language | English |
|---|---|
| Journal | Muscle & Nerve |
| Volume | 49 |
| Issue number | 2 |
| Pages (from-to) | 261-266 |
| Number of pages | 6 |
| ISSN | 0148-639X |
| DOIs | |
| Publication status | Published - Feb 2014 |
- Adolescent, Adult, Biological Markers, Case-Control Studies, Connectin, Creatine Kinase, Energy Metabolism, Exercise, Female, Glycogen, Glycogen Storage Disease Type V, Humans, Male, Middle Aged, Muscle Fibers, Skeletal, Muscle, Skeletal, Muscular Dystrophy, Duchenne, Pilot Projects, Sarcomeres, Troponin I, Young Adult
Research areas
ID: 138430175