Rapid test for fecal calprotectin levels in children with crohn disease
Research output: Contribution to journal › Journal article › Research › peer-review
Assessment of fecal calprotectin, a surrogate marker of mucosal inflammation, is a promising means to monitor therapeutic response in pediatric inflammatory bowel disease, especially if the result is readily available. We tested the performance of a novel calprotectin rapid test, Quantum Blue, versus the conventional enzyme-linked immunosorbent assay in 134 stool samples from 56 pediatric patients with Crohn disease. The intraclass correlation coefficient analysis reflected good agreement (intraclass correlation coefficient 0.97 [95% confidence interval 0.95-0.98]) but agreement was better in lower values, where dilutions were not required. Using a cutoff of 100 μg/g for normal values, the percentage agreement between the 2 tests was 87%. The optimal cutoff values to guide clinical decisions in the therapy of inflammatory bowel disease have yet to be determined.
Original language | English |
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Journal | Journal of Pediatric Gastroenterology and Nutrition |
Volume | 55 |
Issue number | 4 |
Pages (from-to) | 436-9 |
Number of pages | 4 |
ISSN | 0277-2116 |
DOIs | |
Publication status | Published - 2012 |
ID: 48559910