Differential adhesion-inhibitory patterns of antibodies raised against two major variants of the NTS-DBL2X region of VAR2CSA
Research output: Contribution to journal › Journal article › Research › peer-review
VAR2CSA is a large polymorphic Plasmodium falciparum protein expressed on infected erythrocytes (IE) that allows their binding in the placenta, thus precipitating placental malaria (PM). The N-terminal part of VAR2CSA that contains the binding site to placental chondroitin sulfate A (CSA) is currently recognized as the most attractive region for vaccine development. An ultimate challenge is to define epitopes in this region that induce a broad cross-reactive adhesion inhibitory antibody response.
Original language | English |
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Journal | Vaccine |
Volume | 31 |
Issue number | 41 |
Pages (from-to) | 4516-22 |
Number of pages | 7 |
ISSN | 0264-410X |
DOIs | |
Publication status | Published - 23 Sep 2013 |
ID: 80641932