The SH2D2A gene and susceptibility to multiple sclerosis
Research output: Contribution to journal › Journal article › peer-review
We previously reported an association between the SH2D2A gene encoding TSAd and multiple sclerosis (MS). Here a total of 2128 Nordic MS patients and 2004 controls were genotyped for the SH2D2A promoter GA repeat polymorphism and rs926103 encoding a serine to asparagine substitution at amino acid position 52 in TSAd. The GA(16)-rs926103()A haplotype was associated with MS in Norwegians (OR 1.4, P=0.04). A similar trend was observed among Danes. In the independent Norwegian, Danish and Swedish sample sets the GA(16) allele showed a combined OR of 1.13, P=0.05. Thus, the present study shows that the SH2D2A gene may contribute to susceptibility to MS
Udgivelsesdato: 2008/7/15
Udgivelsesdato: 2008/7/15
Original language | English |
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Journal | Journal of Neuroimmunology |
Volume | 197 |
Issue number | 2 |
Pages (from-to) | 152-158 |
Number of pages | 6 |
ISSN | 0165-5728 |
Publication status | Published - 2008 |
ID: 10924678