The SH2D2A gene and susceptibility to multiple sclerosis

Research output: Contribution to journalJournal articlepeer-review

  • A.R. Lorentzen
  • C. Smestad
  • B.A. Lie
  • Annette Bang Oturai
  • E. Akesson
  • J. Saarela
  • K.M. Myhr
  • F. Vartdal
  • E.G. Celius
  • Sørensen, Per Soelberg
  • J. Hillert
  • A. Spurkland
  • H.F. Harbo
We previously reported an association between the SH2D2A gene encoding TSAd and multiple sclerosis (MS). Here a total of 2128 Nordic MS patients and 2004 controls were genotyped for the SH2D2A promoter GA repeat polymorphism and rs926103 encoding a serine to asparagine substitution at amino acid position 52 in TSAd. The GA(16)-rs926103()A haplotype was associated with MS in Norwegians (OR 1.4, P=0.04). A similar trend was observed among Danes. In the independent Norwegian, Danish and Swedish sample sets the GA(16) allele showed a combined OR of 1.13, P=0.05. Thus, the present study shows that the SH2D2A gene may contribute to susceptibility to MS
Udgivelsesdato: 2008/7/15
Original languageEnglish
JournalJournal of Neuroimmunology
Volume197
Issue number2
Pages (from-to)152-158
Number of pages6
ISSN0165-5728
Publication statusPublished - 2008

ID: 10924678