Patch testing with a textile dye mix – a multicentre study

Research output: Contribution to journalJournal articlepeer-review

  • Kristina Ryberg
  • Agner, Tove
  • Klaus E Andersen
  • Andreas Bircher
  • Thomas Diepgen
  • Caterina Foti
  • Ana Giménez-Arnau
  • Margarida Gonçalo
  • An Goossens
  • Johansen, Jeanne Duus
  • Christophe Le Coz
  • Howard I Maibach
  • Magnus Bruze

BACKGROUND: Disperse dyes are well-known contact sensitizers. However, they are not included in the majority of commercially available baseline patch test series.

OBJECTIVES: To investigate the outcome of patch testing with a textile dye mix (TDM) consisting of eight disperse dyes at dermatology clinics in various countries.

PATIENTS/MATERIALS/METHODS: Two thousand nine hundred and seven consecutive dermatitis patients at 12 dermatology clinics representing nine countries were tested with a TDM at 6.6%, consisting of Disperse Blue 35, Disperse Yellow 3, Disperse Orange 1 and 3, and Disperse Red 1 and 17, all at 1.0%, and Disperse Blue 106 and Disperse Blue 124, each at 0.3%, provisionally included in the baseline series. Eighty-seven per cent of the patients allergic to the TDM were also tested with the eight separate dyes.

RESULTS: Contact allergy to TDM was found in 108 patients (3.7%). The frequency of contact allergy varied from 2.1% to 6.9% in different centres. Simultaneous reactivity to p-phenylenediamine was found in 57 of the TDM-positive patients (53%). The most frequent dye allergen among the TDM-positive patients was Disperse Orange 3. The contact allergy could have explained or contributed to the dermatitis in approximately one-third of the patients for whom clinical relevance of the TDM contact allergy was recorded.

CONCLUSIONS: The TDM should be considered for inclusion in the European baseline series.

Original languageEnglish
JournalContact Dermatitis
Volume71
Issue number4
Pages (from-to)215-223
Number of pages9
ISSN0105-1873
DOIs
Publication statusPublished - 2014

    Research areas

  • Adolescent, Adult, Aged, Aged, 80 and over, Azo Compounds, Benzocaine, Child, Child, Preschool, Dermatitis, Allergic Contact, Humans, Male, Middle Aged, Patch Tests, Phenylenediamines, Textiles, Young Adult

ID: 138384211