Effect of a common variant of the PCSK2 gene on reduced insulin secretion
Research output: Contribution to journal › Journal article › Research › peer-review
Individuals at risk of developing type 2 diabetes show a progressive decline in insulin secretion and increased insulin resistance over time. However, inability of the beta cells to compensate for the increased insulin resistance represents a key defect leading to overt type 2 diabetes. The aims of the present study were to replicate the association between genetic variants of the PCSK2 gene and insulin secretion, and to explore the effect on risk of type 2 diabetes.
| Original language | English |
|---|---|
| Journal | Diabetologia |
| Volume | 55 |
| Issue number | 12 |
| Pages (from-to) | 3245-51 |
| Number of pages | 7 |
| ISSN | 0012-186X |
| DOIs | |
| Publication status | Published - Dec 2012 |
- Aged, Blood Glucose, Fasting, Female, Finland, Follow-Up Studies, Genetic Variation, Genotype, Humans, Insulin, Insulin Resistance, Islets of Langerhans, Male, Middle Aged, Predictive Value of Tests, Proprotein Convertase 2, Prospective Studies, Risk Assessment, Sweden
Research areas
ID: 46403756