Polycystic ovary syndrome and low-grade inflammation with special reference to YKL-40
Research output: Contribution to journal › Journal article › Research › peer-review
OBJECTIVE: To evaluate the plasma level of YKL-40 in a Danish polycystic ovary syndrome (PCOS) population and to investigate whether YKL-40 is associated with CVD risk factors such as waist circumference, body mass index (BMI), insulin resistance (IR), fasting glucose, fasting insulin, blood lipids and CRP.
DESIGN: Cross-sectional study.
SETTING: Gynecological clinics at three Danish University Hospitals.
PATIENTS: One hundred seventy-one premenopausal women with PCOS recruited consecutively from April 2010 to February 2012. PCOS was diagnosed according to the Rotterdam criteria.
MAIN OUTCOME MEASURES: Plasma level of YKL-40 in four phenotypes of PCOS defined by BMI and IR.
RESULTS: No statistically significant difference was observed in the plasma level of YKL-40 across the four BMI/IR-phenotypes. Positive associations were observed between YKL-40 and BMI, total and free testosterone, triglycerides, and CRP. Total and free testosterone were independent predictors of YKL-40.
CONCLUSION: YKL-40, the marker of low-grade inflammation is not increased in women with PCOS.
Original language | English |
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Journal | Gynecological Endocrinology |
Volume | 30 |
Issue number | 4 |
Pages (from-to) | 311-315 |
Number of pages | 5 |
ISSN | 0951-3590 |
DOIs | |
Publication status | Published - Apr 2014 |
- Adipokines, Adolescent, Adult, Biological Markers, Body Mass Index, C-Reactive Protein, Cross-Sectional Studies, Denmark, Female, Humans, Inflammation, Insulin, Insulin Resistance, Lectins, Polycystic Ovary Syndrome, Prospective Studies, Regression Analysis, Triglycerides, Waist Circumference, Young Adult
Research areas
ID: 138135940