Non-synonymous polymorphisms in the FCN1 gene determine ligand-binding ability and serum levels of M-ficolin
Research output: Contribution to journal › Journal article › Research › peer-review
The innate immune system encompasses various recognition molecules able to sense both exogenous and endogenous danger signals arising from pathogens or damaged host cells. One such pattern-recognition molecule is M-ficolin, which is capable of activating the complement system through the lectin pathway. The lectin pathway is multifaceted with activities spanning from complement activation to coagulation, autoimmunity, ischemia-reperfusion injury and embryogenesis. Our aim was to explore associations between SNPs in FCN1, encoding M-ficolin and corresponding protein concentrations, and the impact of non-synonymous SNPs on protein function.
Original language | English |
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Journal | P L o S One |
Volume | 7 |
Issue number | 11 |
Pages (from-to) | e50585 |
Number of pages | 10 |
ISSN | 1932-6203 |
DOIs | |
Publication status | Published - 2012 |
ID: 48530749