No association between type 1 diabetes and genetic variation in vitamin D metabolism genes: a Danish study

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BACKGROUND: Vitamin D, certain single nucleotide polymorphisms (SNPs) in the vitamin D-receptor (VDR) gene and vitamin D metabolism genes have been associated with type 1 diabetes (T1D).

OBJECTIVE: We wanted to examine if the most widely studied SNPs in genes important for production, transport, and action of vitamin D were associated with T1D or to circulating levels of vitamin D 25-hydroxyvitamin D [25(OH)D] in a juvenile Danish population.

METHODS: We genotyped eight SNPs in five vitamin D metabolism genes in 1467 trios. 25(OH)D status were analyzed in 1803 children (907 patients and 896 siblings).

RESULTS: We did not demonstrate association with T1D for SNPs in the following genes: CYP27B1, VDR, GC, CYP2R1, DHCR7, and CYP24A1. Though, variants in the GC gene were significantly associated with 25(OH)D levels in the joint model.

CONCLUSION: Some of the most examined SNPs in vitamin D metabolism genes were not confirmed to be associated with T1D, though 25(OH) levels were associated with variants in the GC gene.

Original languageEnglish
JournalPediatric Diabetes
Volume15
Issue number6
Pages (from-to)416-421
Number of pages6
ISSN1399-543X
DOIs
Publication statusPublished - Sep 2014

    Research areas

  • 25-Hydroxyvitamin D3 1-alpha-Hydroxylase, Adolescent, Child, Child, Preschool, Cholestanetriol 26-Monooxygenase, Denmark, Diabetes Mellitus, Type 1, Female, Genetic Association Studies, Genetic Predisposition to Disease, Humans, Infant, Infant, Newborn, Male, Metabolic Networks and Pathways, Oxidoreductases Acting on CH-CH Group Donors, Polymorphism, Single Nucleotide, Receptors, Calcitriol, Vitamin D, Vitamin D-Binding Protein, Vitamin D3 24-Hydroxylase

ID: 138312049