Direct N9-arylation of purines with aryl halides
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An efficient method for N-arylation of purines is reported. The N-arylation is catalysed by Cu(i) and 4,7-bis(2-hydroxyethylamino)-1,10-phenanthroline (BHPhen) in aqueous DMF or ethanol. The reaction generally proceeds with high selectivity for the N(9)-position.
| Original language | English |
|---|---|
| Journal | Chemical Communications |
| Volume | 50 |
| Issue number | 39 |
| Pages (from-to) | 4997-4999 |
| Number of pages | 3 |
| ISSN | 1359-7345 |
| DOIs | |
| Publication status | Published - 21 May 2014 |
| Externally published | Yes |
ID: 189161181